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Table 1 Radiosensitivity of in vivo glioma models

From: Predictive biomarkers of resistance to hypofractionated radiotherapy in high grade glioma

Name

Origin

Xenograft origin

Treatment

Number of mice

Median survival in days

Survival enhancement after RT (%)

p-valuea

Mean TGD in days (%)

Quadrupling Time of RT vs NT p-valueb

CB193

glioma grade III

Cell line

NT

9

42 [37;46]

226

< 0.001

66 ± 13 (351)

< 0.01

RT

6

95 [88;140]

SF763

glioblastoma

Cell line

NT

12

39 [32;52]

226

< 0.01

54 ± 15 (399)

< 0.001

RT

7

88 [81;102]

SF767

glioblastoma

Cell line

NT

8

77 [65;80]

168

< 0.001

52 ± 7 (215)

< 0.001

RT

12

129 [101;140]

T98G

glioblastoma

Cell line

NT

8

20 [16;23]

175

< 0.001

15 ± 5 (259)

< 0.01

RT

8

35 [33;37]

U87MG

glioblastoma

Cell line

NT

6

29 [22;30]

134

< 0.001

11 ± 1 (149)

< 0.01

RT

10

39 [37;41]

U118MG

glioblastoma

Cell line

NT

6

38 [23;49]

179

0.059

26 ± 4 (278)

< 0.01

RT

9

68 [51;79]

GBM-1-HAM

glioblastoma

Patient sample

NT

13

16 [14;18]

319

< 0.001

19 ± 4 (320)

< 0.001

RT

9

51 [37;72]

GBM-14-CHA

glioblastoma

Patient sample

NT

6

16 [14;19]

250

< 0.001

2 ± 1 (115)

ns

RT

10

40 [28;44]

GBM-14-RAV

glioblastoma

Patient sample

NT

6

29 [24;38]

259

< 0.001

37 ± 5 (386)

< 0.01

RT

10

75 [61;82]

ODA-17-GIR

glioma grade III

Patient sample

NT

6

19 [14;25]

405

< 0.001

55 ± 3 (715)

< 0.01

RT

8

77 [65;79]

ODA-4-GEN

glioma grade III

Patient sample

NT

6

26 [20;28]

215

< 0.001

33 ± 3 (462)

< 0.01

RT

8

56 [51;63]

  1. Medians were presented with inter-quartile range [0.25; 0.75] and means with standard-errors
  2. ns not significant, NT Not treated, RT Radiotherapy, TGD Tumor Growth Delay
  3. aLog-rank test
  4. bMann Whitney Test