Skip to main content

Advertisement

Table 3 Prognostic factors of progression free survival and overall survival

From: Biomarkers of resistance to radiation therapy: a prospective study in cervical carcinoma

  Progression-free survival Overall survival
Univariate Cox model Multivariate Cox Model Univariate Cox model Multivariate Cox Model
Variables HR 95% CI HR 95% CI HR 95% CI HR 95% CI
FIGO
IIB 1.00     1.00    
IIIB 1.22 0.72–2.07 1.03 0.57–1.88 2.03 0.87–4.73 1.69 0.64–4.53
Differentiation degree
Well 1.00     1.00    
Moderately 2.35 0.72–7.69 2.89 0.85–9.86 1.65 0.38–7.05 2.42 0.56–10.5
Poorly 1.78 0.45–7.03 1.83 0.46–7.50 0.92 0.15–0.56 0.95 0.15–5.70
Treatment type
Exclusive EBRT + Brachytherapy 1.00     1.00    
Chemo-Radiotherapy + Brachytherapy 0.58 0.35–0.95 0.57 0.32–1.00 0.38 0.18–0.80 0.36 0.16–0.82
Tumor protein strong expression
SURVIVIN 1.02 0.46–2.28 1.37 0.51–3.67 1.35 0.40–4.47 1.80 0.51–6.46
IGF1R-β 1.53 0.81–2.89 1.81 0.87–3.76 2.7 0.94–7.73 5.38 1.59–18.3
IGF1R-α 1.07 0.57–1.98 1.08 0.54–2.17 1.58 0.60–4.12 2.06 0.70–6.12
GLUT-1 0.99 0.54–1.83 1.04 0.55–1.98 1.66 0.77–3.55 2.22 0.99–5.04
HIF-1α 1.46 0.79–2.70 1.56 0.80–3.05 0.92 0.42–2.00 0.94 0.41–2.17
CAIX 0.52 0.20–1.32 0.50 0.20–0.30 0.53 0.16–1.77 0.58 0.17–2.02
Impact of anemia
Hb 2.20 1.33–3.65 1.78 1.00–3.15 2.11 1.04–4.33 2.01 0.92–4.40
  1. HR Hazard ratio, CI Confidence interval, FIGO International Federation of Gynecology and Obstetrics, EBRT External beam radiotherapy