Author | Study | Nr. of patients | CTP | Diameter (cm)a | Fractionation | LC@1Â year | mOS | Toxicity |
---|---|---|---|---|---|---|---|---|
Mendez Romero [23] | Pr. | 5 2 | A B | 4.7 | 3-5 × 5–12 Gy | 75% | 22 | 1 lethal liver failure |
Tse [34] | Pr. | 31 | A | 173cm3b | 6 × 4–9 Gy | 65% | 11.7 | 8 grade 3 enzyme elevations, 1 pulmonary embolism, 1 tumor-duodenal connection |
Jang [35] | Ret | 74 8 | A B | 3 | 3 × 11-20Gy | 87%@ 2 y. | 63%@ 2 y. | 5 GI toxicity grade 3 6 CTP elevation >2 |
Huang [36] | Ret | 23 4 1 | A B C | 4.4 | 10 × 4.5 Gy 18–20 × 2.5 Gy 18–20 × 1.8 Gy | 87.6% | 23 | 1 grade 3 gastric ulcer |
Bae [37] | Ret | 18 2 | A B | <3 cm (80%) 3-5 cm (20%) | 5 × 10 Gy | 85% | 100@ 1 y. | No grade 3 toxicities |
Jung [38] | Ret | 68 24 | A B | 8.6 cm3b | 3-4 × 10-20Gy | 92%@ 3 y. |  | 6 patients grade 3 RILD |
Wahl [12] | Ret. | 57 24 2 | A B C | <2 cm (48%) 2-3 cm (26%) 3-5 cm (23%) >5 cm (3.7%) | 3-5 × 6–10Gy | 97.4% | 74%@ 1 y. | 1 RILD, 1 GI bleeding 1 worsening ascites |
Andolino [9] | Ret. | 36 24 | A B | 3.1 cm | 3-5 × 8-16Gy | 90%@ 2 y. | 48%@ 2 y. | 20% CTP progression |
Bibault [22] | Ret. | 66 9 | A B | 3.7 cm | 3 × 8-15Gy | 89.8% | 15 | 5 liver decompensations, 1 grade 4 gastric ulcer, 3 grade 2 duodenal ulcers |
Huertas [21] | Ret. | 76 11 | A B | 2.4 cm | 3x15Gy | 99% | 82%@ 1 y. | 1 grade 5 hematemesis 2 grade > 3 gastric ulcers |
Scorsetti [24] | Ret. | 23 20 | A B | 4.8 cm | 3 × 16–25 Gy 6 × 6–10 Gy | 86% | 18 | 7 grade > 3 liver enzyme elevations |
Seo [39] | Ret. | 34 4 | A B | 40.5mlb | 3 × 11-12 Gy | 79% | 32 | 1 grade 3 soft tissue toxicity |
Kwon [40] | Ret. | 38 4 | A | 15.4mlb | 3 × 10-13Gy | 72% | 93%@ 1 y. | 1 radiation induced hepatic failure |
Takeda [41] | Ret. | 14 2 | A B | 1.9-7 cm | 5-7 × 5-10Gy | 100% | 100% | 1 RILD |
Price [42] | Ret. | 14 12 | A B | max. 6 cm | 3-5 × 8-16Gy | 97% | 77% | 20% CTP worsening |
Kang [43] | Pr. | 41 6 | A B | 2.9 cm | 3 × 14-20Gy | 94%@ 2 y. | 68.7@ 2 y. | 3 grade 3 GI toxicity, 2 grade 4 gastric ulcers |
Su [44] | Ret | 114 18 | A B | 1.1–5.0 cm | 1 × 28-30Gy 42–46 Gy in 3–5 fractctions | 90% |  | 11 patients hepatic toxicity grade ≥ 3 |
Kang [45] | Ret | 67 34 | A B | n.s. | 6 fractions | 20–29.4 @ 2y | 12–15 | 25 cases deteriorated from grade A to B, 4 from A to C and 6 from B to C |
Sanuki [46] | Ret | 158 27 | A B | 2.7 (0.8–5) cm | 5 × 7–8 Gy | 91% @ 3 y. | 70% @ 3 y. | 13% acute grade > 3, 2 grade 5 liver failure |
Kimura [47] | Ret | 56 9 | A B | 1.6 cm | 4 × 12 Gy | 100% @ 2 y. | 76% @ 2 y. | 23% grade > 3 |
Weiner [26] | Pr. | 12 | A,B | ca. 5 cm | 5 × 8–11 Gy | 91% | 38%@ 1 y. | 9 CTP decline 2 grade 5hepatic failure |
Que [48] | Ret | 104 11 | A B | ≤ 4 cm (35%) 4–9 cm (41%) ≥10 cm (24%) | 26–40 Gy in 3–5 fract. | 85% | 15 | 3 patients grade 5 25 patients grade 3 |
Que [27] | Ret. | 22 2 | A B | 11.4 cm | 5 × 5.2-8Gy | 55.6% | 11 | 1 grade 3 liver enzyme elevation |
Bujold [10] | Pr. | 102 0 | A B | 7.2 cm | 6 × 4-9Gy | 88% | 17 | 6 grade > 3 liver failures, 1 grade 5 cholangitis, 1 grade 5 GI bleed 16 grade ≥ 3 enzyme elevations |
Culleton [33] | Pr./ Ret. | 0 29 | A B | 5.1 cm | 5–15 fractions 19.7–46.8Gyc | n.a. | 7.9 | 63% CTP decline ≥ 2 points, 5 grade 3 thrombocytopenia, 3 > grade 3 elevation of liver enzymes |
Current study | Ret | 28 19 | A B | 7 cm | 3-12 × 4-15Gy | 77% | 9 | 1 RILD, 1 grade 5 liver decompensation, 1 grade 3 GI-bleed, 1 necrotic abscess |