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Table 4 Review of Literature

From: Excellent local control and tolerance profile after stereotactic body radiotherapy of advanced hepatocellular carcinoma

Author

Study

Nr. of patients

CTP

Diameter (cm)a

Fractionation

LC@1 year

mOS

Toxicity

Mendez Romero [23]

Pr.

5

2

A

B

4.7

3-5 × 5–12 Gy

75%

22

1 lethal liver failure

Tse [34]

Pr.

31

A

173cm3b

6 × 4–9 Gy

65%

11.7

8 grade 3 enzyme elevations, 1 pulmonary embolism, 1 tumor-duodenal connection

Jang [35]

Ret

74

8

A

B

3

3 × 11-20Gy

87%@

2 y.

63%@

2 y.

5 GI toxicity grade 3

6 CTP elevation >2

Huang [36]

Ret

23

4

1

A

B

C

4.4

10 × 4.5 Gy

18–20 × 2.5 Gy

18–20 × 1.8 Gy

87.6%

23

1 grade 3 gastric ulcer

Bae [37]

Ret

18

2

A

B

<3 cm (80%)

3-5 cm (20%)

5 × 10 Gy

85%

100@

1 y.

No grade 3 toxicities

Jung [38]

Ret

68

24

A

B

8.6 cm3b

3-4 × 10-20Gy

92%@

3 y.

 

6 patients grade 3 RILD

Wahl [12]

Ret.

57

24

2

A

B

C

<2 cm (48%)

2-3 cm (26%)

3-5 cm (23%)

>5 cm (3.7%)

3-5 × 6–10Gy

97.4%

74%@

1 y.

1 RILD, 1 GI bleeding

1 worsening ascites

Andolino [9]

Ret.

36

24

A

B

3.1 cm

3-5 × 8-16Gy

90%@

2 y.

48%@

2 y.

20% CTP progression

Bibault [22]

Ret.

66

9

A

B

3.7 cm

3 × 8-15Gy

89.8%

15

5 liver decompensations, 1 grade 4 gastric ulcer, 3 grade 2 duodenal ulcers

Huertas [21]

Ret.

76

11

A

B

2.4 cm

3x15Gy

99%

82%@

1 y.

1 grade 5 hematemesis

2 grade > 3 gastric ulcers

Scorsetti [24]

Ret.

23

20

A

B

4.8 cm

3 × 16–25 Gy

6 × 6–10 Gy

86%

18

7 grade > 3 liver enzyme

elevations

Seo [39]

Ret.

34

4

A

B

40.5mlb

3 × 11-12 Gy

79%

32

1 grade 3 soft tissue toxicity

Kwon [40]

Ret.

38

4

A

15.4mlb

3 × 10-13Gy

72%

93%@

1 y.

1 radiation induced hepatic failure

Takeda [41]

Ret.

14

2

A

B

1.9-7 cm

5-7 × 5-10Gy

100%

100%

1 RILD

Price [42]

Ret.

14

12

A

B

max. 6 cm

3-5 × 8-16Gy

97%

77%

20% CTP worsening

Kang [43]

Pr.

41

6

A

B

2.9 cm

3 × 14-20Gy

94%@

2 y.

68.7@

2 y.

3 grade 3 GI toxicity,

2 grade 4 gastric ulcers

Su [44]

Ret

114

18

A

B

1.1–5.0 cm

1 × 28-30Gy

42–46 Gy in 3–5 fractctions

90%

 

11 patients hepatic toxicity grade ≥ 3

Kang [45]

Ret

67

34

A

B

n.s.

6 fractions

20–29.4 @ 2y

12–15

25 cases deteriorated from grade

A to B, 4 from A to C and 6 from B to C

Sanuki [46]

Ret

158

27

A

B

2.7 (0.8–5) cm

5 × 7–8 Gy

91% @ 3 y.

70% @ 3 y.

13% acute grade > 3, 2 grade 5 liver failure

Kimura [47]

Ret

56

9

A

B

1.6 cm

4 × 12 Gy

100% @ 2 y.

76% @ 2 y.

23% grade > 3

Weiner [26]

Pr.

12

A,B

ca. 5 cm

5 × 8–11 Gy

91%

38%@

1 y.

9 CTP decline

2 grade 5hepatic failure

Que [48]

Ret

104

11

A

B

≤ 4 cm (35%)

4–9 cm (41%)

≥10 cm (24%)

26–40 Gy in 3–5 fract.

85%

15

3 patients grade 5

25 patients grade 3

Que [27]

Ret.

22

2

A

B

11.4 cm

5 × 5.2-8Gy

55.6%

11

1 grade 3 liver enzyme

elevation

Bujold [10]

Pr.

102

0

A

B

7.2 cm

6 × 4-9Gy

88%

17

6 grade > 3 liver failures, 1 grade 5 cholangitis, 1 grade 5 GI bleed

16 grade ≥ 3 enzyme elevations

Culleton [33]

Pr./

Ret.

0

29

A

B

5.1 cm

5–15 fractions

19.7–46.8Gyc

n.a.

7.9

63% CTP decline ≥ 2 points, 5 grade 3 thrombocytopenia, 3 > grade 3 elevation of liver enzymes

Current study

Ret

28

19

A

B

7 cm

3-12 × 4-15Gy

77%

9

1 RILD, 1 grade 5 liver decompensation, 1 grade 3 GI-bleed,

1 necrotic abscess

  1. amedian
  2. bVolume
  3. cMin dose to 95% to PTV
  4. CTP score Child-Turcotte-Pugh score, LC @ 1 year local control at 1 year, mOS median overall survival, GI Gastro-intestinal, RILD Radiation induced liver disease