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Table 1 LET and survival parameters for OE21 and KYSE450

From: Difference in the relative biological effectiveness and DNA damage repair processes in response to proton beam therapy according to the positions of the spread out Bragg peak

OE21

LET (keV / μm)

α (Gy−1)

β (Gy−2)

α/β (Gy)

D10 (Gy)

D37 (Gy)

RBE10

RBE37

6MV X-ray

2.36

0.06 ± 0.03

0.06 ± 0.01

0.88

5.63 ± 0.14

3.55 ± 0.13

  

 #1

2.85

0.17 ± 0.03

0.05 ± 0.01

3.23

5.36 ± 0.29

3.07 ± 0.05

1.06 ± 0.04

1.16 ± 0.03

 #2

4.65

0.23 ± 0.03

0.05 ± 0.01

4.37

4.80 ± 0.10

2.68 ± 0.08

1.17 ± 0.02

1.33 ± 0.04

 #3

5.64

0.16 ± 0.07

0.07 ± 0.02

2.16

4.63 ± 0.15

2.71 ± 0.06

1.22 ± 0.03

1.31 ± 0.03

 #4

8.14

0.24 ± 0.05

0.06 ± 0.01

4.05

4.56 ± 0.11

2.57 ± 0.16

1.24 ± 0.03

1.40 ± 0.06

KYSE450

LET (keV / μm)

α

β

α/β

D10

D37

RBE10

RBE37

6MV X-ray

2.36

0.06 ± 0.02

0.02 ± 0.00

3.40

9.55 ± 0.30

5.81 ± 0.30

  

 #1

2.85

0.05 ± 0.03

0.02 ± 0.00

2.38

9.25 ± 0.13

5.70 ± 0.16

1.03 ± 0.02

1.02 ± 0.04

 #2

4.65

0.08 ± 0.04

0.02 ± 0.01

3.81

9.06 ± 0.20

5.35 ± 0.22

1.06 ± 0.02

1.09 ± 0.04

 #3

5.64

0.07 ± 0.03

0.03 ± 0.01

2.64

7.98 ± 0.18

4.82 ± 0.07

1.20 ± 0.03

1.21 ± 0.04

 #4

8.14

0.09 ± 0.03

0.03 ± 0.00

3.11

7.68 ± 0.03

4.61 ± 0.15

1.24 ± 0.02

1.27 ± 0.05

  1. LET linear energy transfer, D 10 dose required to reduce the fraction of surviving cells to 10%, D 37 dose required to reduce the fraction of surviving cells to 37%, RBE 10 relative biological effectiveness at the survival dose of 10%, RBE 37 relative biological effectiveness at the survival dose of 37%