Table 3 Selected studies on combined radiochemotherapy in older patients with glioblastoma
From: Radiation therapy for older patients with brain tumors
Authors | Type of study | Patients | Age years | RT dose Gy/fractions | CHT | median PFS months | median OS months |
|---|---|---|---|---|---|---|---|
Brandes et al. [56] | Prospective | 24 32 22 | ≥65 ≥ 65 ≥ 65 | 59.4/33 59.4/33 59.4/33 | no PCV TMZ | 5.3 (8.3% at 1 year) 6.9 (15.6% at 1 year) 10.7 (47.4% at 1 year) | 11.2 (31.6% at 1 year) 12.7 (56.2% at 1 year) 14.9 (72.5% at 1 year) |
Minniti G et al. [58] | Prospective | 32 | ≥70 | 60/30 | TMZ | 6.7 (16% at 1 year) | 10.8 (37% at 1 year) |
Brandes et al. [59] | Prospective | 58 | ≥65 | 60/30 | TMZ | 9.5 (35% at 1 year) | 13.7 (31.4% at 2 years) |
Minniti G et al. [61] | Prospective | 43 | ≥70 | 30/6 | TMZ | 6.3 (12% at 1 year) | 9.3 (35% at 1 year) |
Minniti et al. [66] | Prospective | 70 | ≥70 | 40/15 | TMZ | 6 (20% at 1 years | 12.4 (58% at 1 year) |
Perry et al. [67] | Randomized | 178a 195a | >65 > 65 | 40/15 40/15 | no TMZ | 4.7 (9.3% at 1 year) 3.3 (12% at 1 year) | 9.6 (37.4% at 1 year) 8.6 (34.4% at 1 year) |