Outcomes | Type of Evidence | Quality | Consistency | Directness | Effect Size | Total | Overall Quality |
|---|
Local Control | +2 | −2 | 0 | 0 | 0 | 0 | Very low |
Distant Progression | +2 | −2 | 0 | 0 | 0 | 0 | Very low |
LMD | +2 | −2 | −1 | 0 | +1 | 0 | Very low |
Overall Survival | +2 | −2 | −1 | 0 | 0 | −1 | Very low |
- Type of evidence is based on the study design of the included studies and ranges from +2 to +4. Study quality is graded based on blinding and allocation, follow up and withdrawals, sparsity of data, or methodological concerns and ranges from −3 to 0. Consistency is graded based on heterogeneity of populations and study end points with respect to one another and included populations and ranges from −1 to +1. Directness is graded based on generalizability of the included results and is graded from −2 to 0. Effect size is graded on the value of the RR or OR and is graded from 0 to +2. The overall quality of the recommendations that can be made based on the included studies includes the following categories: high (at least 4 points overall), moderate (3 points), low (2 points), and very low (1 point or less)
