Stereotactic radiosurgery versus whole-brain radiotherapy after intracranial metastasis resection: a systematic review and meta-analysis

Lamba, Nayan; Muskens, Ivo S.; DiRisio, Aislyn C.; Meijer, Louise; Briceno, Vanessa; Edrees, Heba; Aslam, Bilal; Minhas, Sadia; Verhoeff, Joost J. C.; Kleynen, Catharina E.; Smith, Timothy R.; Mekary, Rania A.; Broekman, Marike L.

doi:10.1186/s13014-017-0840-x

Table 1 Characteristics of the studies included in the systematic review (n = 8) and meta-analysis (n = 6)

From: Stereotactic radiosurgery versus whole-brain radiotherapy after intracranial metastasis resection: a systematic review and meta-analysis

Author (year of publication)	Total Number of patients	Treatment modality (number of patients)	Number of Cases (number of metastases)	Mean Age	Pathology of the metastasis								Radiation dose (Scheme)	Radiation dose (EQD2)	NOS score
Author (year of publication)	Total Number of patients	Treatment modality (number of patients)	Number of Cases (number of metastases)	Mean Age	Lung (SC)	Lung (NSC)	Melanoma	Colon	Renal	Breast	Other	Unknown	Radiation dose (Scheme)	Radiation dose (EQD2)	NOS score
Elaimy (2011) ^a ¹⁶	275	Resection + WBRT (11 patients)	7 patients (1 metastasis) 4 patients (unknown)	60	2	6	1	0	UA	0	0	2	Median: 30 Gy (NA)	37.5 Gy	7
Elaimy (2011) ^a ¹⁶	275	Resection + SRS (15 patients)	10 patients (1 metastasis) 3 patients (2–4 metastases)	57	1	6	4	UA	2	0	2	0	Median: 18 Gy (1 dose)	90.0 Gy	7
Gu (2015)¹⁷	93	Resection + WBRT (19 patients)	37 patients (1 metastasis) 8 patients (2–3 metastases)	UA	0	0	0	19	0	0	0	0	30 Gy (10x3Gy)	37.5 Gy	6
		Resection + WBRT (19 patients)		UA	0	0	0	19	0	0	0	0	40 Gy (20x2 Gy)	40.0 Gy
		Resection + SRS (11 patients)		UA	0	0	0	11	0	0	0	0	12–24 Gy (1 dose)	42.0−> 110.0Gy
Hsieh (2015)¹⁸	212	Resection + WBRT (156 patients)	83 patients (1 metastasis) 52 patients (2–3 metastases)	58	UA	78	17	UA	UA	24	31	UA	30 Gy (10 x 3 Gy)	37.5 Gy	7
		Resection + WBRT (156 patients)	83 patients (1 metastasis) 52 patients (2–3 metastases)	58	UA	78	17	UA	UA	24	31	UA	37.5 Gy (15x2.5 Gy)	42.2 Gy
		Resection + SRS (56 patients)	42 patients (1 metastasis) 14 patients (2–3 metastases)	60	UA	30	5	UA	UA	6	14	UA	18 Gy (1 dose)	56.0−> 110.0 Gy
Hwang (2010) ^a19	43	Resection + WBRT (18 patients)	1.67 +/− 0.91 ^b	52.8	1	12	UA	UA	UA	1	2	2	UA	UA	7
Hwang (2010) ^a19	43	Resection + SRS (25 patients)	1.54 +/− 0.72 ^b	59.47	1	15	UA	UA	UA	4	3	0	UA	UA	7
Lee (2013) ^a5	157	Resection + WBRT (109 patients)	96 patients (1 metastasis) 61 patients (2–3 metastases)	UA	UA	UA	UA	UA	UA	UA	UA	UA	30 Gy (10x3 Gy)	37.5 Gy	7
		Resection + WBRT (109 patients)		UA	UA	UA	UA	UA	UA	UA	UA	UA	40 Gy (20x2 Gy)	40.0 Gy
		Resection + SRS (17 patients)		UA	UA	UA	UA	UA	UA	UA	UA	UA	15–24 Gy (1 dose)	63.8−> 110 Gy
Patel (2014)²⁴	132	Resection + WBRT (36 patients)	14 patients (1 metastasis) 22 patients (2–3 metastases)	54.6	UA	15	UA	UA	UA	UA	21?	UA	30 Gy (10x3Gy)	37.5 Gy	8
		Resection + WBRT (36 patients)	14 patients (1 metastasis) 22 patients (2–3 metastases)	54.6	UA	15	UA	UA	UA	UA	21?	UA	37.5 Gy	42.2 Gy
		Resection + SRS (96 patients)	68 patients (1 metastasis) 28 patients (2–3 metastases)	56	0	45	UA	UA	UA	UA	51	UA	15–21Gy (1 dose)	63.8−> 110.0 Gy
Salvati (1997) ^a28	19	Resection + WBRT (14 patients)	14 patients (1 metastasis)	UA	0	0	14	0	0	0	0	0	40–50Gy (NA)	40.0–50.0 Gy	6
Salvati (1997) ^a28	19	Resection + SRS (5 patients)	5 patients (1 metastasis)	UA	0	0	5	0	0	0	0	0	UA	UA	6
Caroli (2011)²⁹	204	Resection + WBRT (45 patients)	Not available	UA	UA	UA	UA	UA	UA	UA	UA	UA	UA	UA	7
Caroli (2011)²⁹	204	Resection + SRS (13 patients)	Not available	UA	UA	UA	UA	UA	UA	UA	UA	UA	UA	UA	7

Abbreviations: SRS Stereotactic Radiosurgery, WBRT Whole Brain Radiotherapy, SC Small-cell, NSC Non-Small Cell, Gy Gray, NOS New-Castle Ottawa, UA Unavailable, EQD2 equivalent dose in 2-Gy fractions (EQD2(α/β = 2)), RCS Retrospective cohort study
^a included in the meta-analysis
^b reported as mean +/− SD

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