Intensity-modulated radiation therapy from 70Gy to 80Gy in prostate cancer: six- year outcomes and predictors of late toxicity

Table 3 Rectal toxicity pronostic factors

Characteristics	Bivariate analysis		Multivariate analysis
Characteristics	HR and 95% CI	p-value	HR and 95% CI	p-value
Age^a
≤70	1
>70	0.44 [0.15; 1.28]	0.13	-	-
Stage
T1c + 2a	1
T2b	1.68 [0.52; 5.46]	0.39
T2c-T4	0.69 [0.15; 3.19]	0.63
Diabetes
No	1
Yes	1.84 [0.59; 5.80]	0.30
HBP
No	1
Yes	0.55 [0.20; 1.53]	0.25
Pelvic surgery
No	1
Yes	0.89 [0.32; 2.52]	0.84
Previous TURP
No	1
Yes	0.98 [0.22; 4.36]	0.98
ADT^a
No	2.46 [0.78;7.74]	0.12
Yes	1	0.12
Anticoagulation treatment^a
No	1
Yes	1.30 [0.47; 3.59]	0.61	-	-
RTH total dose
70 Gy	1
74 Gy	1.06 [0.13;8.82]	0.96
80 Gy	3.12 [0.39;24.98]	0.28
RTH total dose^a
70Gy-74Gy	1
80 Gy	2.96 [1.07; 8.20]	0.04	2.96 [1.07; 8.20]	0.04

Abbreviations: HR hazard ratio, CI 95% 95% confidence interval, HBP high blood pressure, TURP transurethral prostate resection, ADT androgen deprivation therapy, anticoagulation treatment anticoagulation or antiplatelet treatment, RTH radiotherapy
^aParameters included in backward multivariate analysis

ISSN: 1748-717X