Outcome of proximal esophageal cancer after definitive combined chemo-radiation: a Swiss multicenter retrospective study

Table 2 Univariate analysis of prognostic factors influencing OS, DFS, and LRC in cervical esophageal cancer

Factor	3-year LRC (%)	p-value	3-year DFS (%)	p-value	3-year OS (%)	p-value
Gender
Female	51	0.71	17	0.28	42	0.2
Male	53		42		56
Age
≤ 65y	66	0.25	41	0.82	54	0.64
≥ 65y	39		30		52
Tumor grade
G2	55	0.14	44	0.34	68	0.12
G3	57		32		46
TNM
T1-2	54	0.62	26	0.27	56	0.7
T3-4	45	0.50	39	0.42	40	0.81
N0	57		44		49
N+	50		31		53
ICHT
No	41	0.18	25	0.11	40	0.11
Yes	60		43		60
Time to RT
≤ 78days	43	0.24	24	0.03	53	0.45
≥ 78days	59		46		52
RT Modality
3-D	47	0.5	36	0.68	60	0.75
IMRT	55		36		47
Dysphagia before treatment
0	53	0.67	53	0.83	53	0.51
G1	57		34		48
G2	57		36		59
G3	29		25		37
RT dose
≥ 56Gy	56	0.76	36	0.78	56	0.88
≤ 56Gy	50		35		49

ICHT induction chemotherapy, RT radiation treatment, LRC loco-regional control, DFS disease-free survival, OS overall survival

ISSN: 1748-717X