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Table 3 Organs at risk for the 90-patient cohort

From: Sparing of normal tissues with volumetric arc radiation therapy for glioblastoma: single institution clinical experience

 

Median (Range)

IMRT

VMAT

P*

Braina

 Dmean (Gy)

26.7 (12.0–36.5)

27.6 (15.8–36.0)

0.41

 Dmax (Gy)

63.8 (62.6–66.2)

63.5 (62.0–64.9)

0.07

 V30Gy (%)

34.5 (11.4–58.0)

38.0 (19.3–61.5)

0.16

 V60Gy (%)

3.7 (0.7–9.6)

3.3 (1.1–12.1)

0.62

Brainb

 GI50Gy

1.9 (1.5–2.3)

1.9 (1.5–2.4)

0.08

 GI60Gy

5.0 (2.8–31.6)

6.4 (2.3–13.2)

0.05

Brainstem

 Dmean (Gy)

28.7 (7.8–46.3)

19.3 (0.8–39.2)

<0.001

 Dmax (Gy)

53.7 (18.2–61.6)

53.2 (2.2–60.4)

0.13

 V30Gy (%)

39.2 (0.0–88.1)

26.1 (0.0–71.4)

0.005

Ipsilateral Hippocampus

 Dmean (Gy)

53.0 (16.0–62.5)

46.8 (1.6–62.3)

0.06

 Dmax (Gy)

60.5 (24.2–64.0)

55.7 (3.2–63.5)

0.12

 D100% (Gy)

31.7 (3.0–59.1)

19.7 (1.0–59.6)

0.03

Contralateral Hippocampus

 Dmean (Gy)

20.3 (10.9–55.9)

22.5 (0.9–55.8)

0.25

 Dmax (Gy)

34.7 (18.3–61.9)

39.3 (1.7–62.8)

0.26

 D100% (Gy)

13.1 (2.1–46.3)

13.4 (0.7–50.8)

0.88

Bilateral Hippocampus

 Dmean (Gy)

35.7 (13.7–57.0)

35.1 (1.3–56.3)

0.79

 Dmax (Gy)

60.5 (24.2–64.0)

56.0 (3.2–63.5)

0.15

 D100% (Gy)

12.3 (2.1–46.3)

11.6 (0.7–47.0)

0.95

Optic Chiasm

 Dmean (Gy)

35.8 (1.3–52.9)

35.7 (1.5–52.5)

0.84

 Dmax (Gy)

51.6 (2.3–55.7)

51.3 (1.8–53.9)

0.52

Ipsilateral Optic Nerve

 Dmean (Gy)

20.9 (0.7–49.7)

20.7 (0.9–47.8)

0.73

 Dmax (Gy)

35.9 (1.1–55.7)

43.6 (1.3–54.5)

0.72

Contralateral Optic Nerve

 Dmean (Gy)

9.9 (0.6–46.4)

12.2 (0.8–44.9)

0.46

 Dmax (Gy)

19.5 (1.0–55.0)

23.6 (1.2–54.7)

0.80

Ipsilateral Cochlea

 Dmean (Gy)

25.6 (3.0–61.9)

5.9 (0.5–48.2)

<0.001

 Dmax (Gy)

30.8 (3.6–62.3)

6.8 (0.6–53.7)

<0.001

Contralateral Cochlea

 Dmean (Gy)

12.7 (1.7–25.8)

3.2 (0.4–20.0)

<0.001

 Dmax (Gy)

15.0 (2.0–29.6)

3.8 (0.4–23.7)

<0.001

Ipsilateral Eye

 Dmean (Gy)

3.6 (0.4–24.4)

5.1 (0.6–22.5)

0.08

 Dmax (Gy)

7.9 (1.0–49.6)

15.1 (1.0–46.5)

0.32

Contralateral Eye

 Dmean (Gy)

3.1 (0.4–8.5)

4.0 (0.6–20.9)

0.08

 Dmax (Gy)

7.1 (0.5–40.2)

9.9 (1.0–37.2)

0.07

Ipsilateral Lens

 Dmean (Gy)

2.2 (0.4–5.6)

2.7 (0.5–14.4)

0.18

 Dmax (Gy)

2.6 (0.4–8.3)

3.1 (0.6–16.8)

0.41

Contralateral Lens

 Dmean (Gy)

1.7 (0.3–19.7)

2.4 (0.5–14.3)

0.02

 Dmax (Gy)

2.0 (0.3–31.2)

2.7 (0.6–17.1)

0.05

  1. IMRT intensity modulated radiation therapy, VMAT volumetric arc therapy, D min minimum dose, D mean mean dose, D max maximum dose, D100% maximum dose covering 100% of organ, V XXGy volume receiving XX Gy or more, GI gradient index
  2. *From Wilcoxon-Mann–Whitney rank sum analysis aBrain organ at risk volume excludes the gross tumor volume, brainstem and optic chiasm volumes bBrain volume does not exclude the gross tumor volume, brainstem and optic chiasm volumes