| |
Median (Range)
|
|---|
|
IMRT
|
VMAT
|
P*
|
|---|
|
Braina
|
|
Dmean (Gy)
|
26.7 (12.0–36.5)
|
27.6 (15.8–36.0)
|
0.41
|
|
Dmax (Gy)
|
63.8 (62.6–66.2)
|
63.5 (62.0–64.9)
|
0.07
|
|
V30Gy (%)
|
34.5 (11.4–58.0)
|
38.0 (19.3–61.5)
|
0.16
|
|
V60Gy (%)
|
3.7 (0.7–9.6)
|
3.3 (1.1–12.1)
|
0.62
|
|
Brainb
|
|
GI50Gy
|
1.9 (1.5–2.3)
|
1.9 (1.5–2.4)
|
0.08
|
|
GI60Gy
|
5.0 (2.8–31.6)
|
6.4 (2.3–13.2)
|
0.05
|
|
Brainstem
|
|
Dmean (Gy)
|
28.7 (7.8–46.3)
|
19.3 (0.8–39.2)
|
<0.001
|
|
Dmax (Gy)
|
53.7 (18.2–61.6)
|
53.2 (2.2–60.4)
|
0.13
|
|
V30Gy (%)
|
39.2 (0.0–88.1)
|
26.1 (0.0–71.4)
|
0.005
|
|
Ipsilateral Hippocampus
|
|
Dmean (Gy)
|
53.0 (16.0–62.5)
|
46.8 (1.6–62.3)
|
0.06
|
|
Dmax (Gy)
|
60.5 (24.2–64.0)
|
55.7 (3.2–63.5)
|
0.12
|
|
D100% (Gy)
|
31.7 (3.0–59.1)
|
19.7 (1.0–59.6)
|
0.03
|
|
Contralateral Hippocampus
|
|
Dmean (Gy)
|
20.3 (10.9–55.9)
|
22.5 (0.9–55.8)
|
0.25
|
|
Dmax (Gy)
|
34.7 (18.3–61.9)
|
39.3 (1.7–62.8)
|
0.26
|
|
D100% (Gy)
|
13.1 (2.1–46.3)
|
13.4 (0.7–50.8)
|
0.88
|
|
Bilateral Hippocampus
|
|
Dmean (Gy)
|
35.7 (13.7–57.0)
|
35.1 (1.3–56.3)
|
0.79
|
|
Dmax (Gy)
|
60.5 (24.2–64.0)
|
56.0 (3.2–63.5)
|
0.15
|
|
D100% (Gy)
|
12.3 (2.1–46.3)
|
11.6 (0.7–47.0)
|
0.95
|
|
Optic Chiasm
|
|
Dmean (Gy)
|
35.8 (1.3–52.9)
|
35.7 (1.5–52.5)
|
0.84
|
|
Dmax (Gy)
|
51.6 (2.3–55.7)
|
51.3 (1.8–53.9)
|
0.52
|
|
Ipsilateral Optic Nerve
|
|
Dmean (Gy)
|
20.9 (0.7–49.7)
|
20.7 (0.9–47.8)
|
0.73
|
|
Dmax (Gy)
|
35.9 (1.1–55.7)
|
43.6 (1.3–54.5)
|
0.72
|
|
Contralateral Optic Nerve
|
|
Dmean (Gy)
|
9.9 (0.6–46.4)
|
12.2 (0.8–44.9)
|
0.46
|
|
Dmax (Gy)
|
19.5 (1.0–55.0)
|
23.6 (1.2–54.7)
|
0.80
|
|
Ipsilateral Cochlea
|
|
Dmean (Gy)
|
25.6 (3.0–61.9)
|
5.9 (0.5–48.2)
|
<0.001
|
|
Dmax (Gy)
|
30.8 (3.6–62.3)
|
6.8 (0.6–53.7)
|
<0.001
|
|
Contralateral Cochlea
|
|
Dmean (Gy)
|
12.7 (1.7–25.8)
|
3.2 (0.4–20.0)
|
<0.001
|
|
Dmax (Gy)
|
15.0 (2.0–29.6)
|
3.8 (0.4–23.7)
|
<0.001
|
|
Ipsilateral Eye
|
|
Dmean (Gy)
|
3.6 (0.4–24.4)
|
5.1 (0.6–22.5)
|
0.08
|
|
Dmax (Gy)
|
7.9 (1.0–49.6)
|
15.1 (1.0–46.5)
|
0.32
|
|
Contralateral Eye
|
|
Dmean (Gy)
|
3.1 (0.4–8.5)
|
4.0 (0.6–20.9)
|
0.08
|
|
Dmax (Gy)
|
7.1 (0.5–40.2)
|
9.9 (1.0–37.2)
|
0.07
|
|
Ipsilateral Lens
|
|
Dmean (Gy)
|
2.2 (0.4–5.6)
|
2.7 (0.5–14.4)
|
0.18
|
|
Dmax (Gy)
|
2.6 (0.4–8.3)
|
3.1 (0.6–16.8)
|
0.41
|
|
Contralateral Lens
|
|
Dmean (Gy)
|
1.7 (0.3–19.7)
|
2.4 (0.5–14.3)
|
0.02
|
|
Dmax (Gy)
|
2.0 (0.3–31.2)
|
2.7 (0.6–17.1)
|
0.05
|
-
IMRT intensity modulated radiation therapy, VMAT volumetric arc therapy, D
min
minimum dose, D
mean
mean dose, D
max
maximum dose, D100% maximum dose covering 100% of organ, V
XXGy
volume receiving XX Gy or more, GI gradient index
- *From Wilcoxon-Mann–Whitney rank sum analysis aBrain organ at risk volume excludes the gross tumor volume, brainstem and optic chiasm volumes bBrain volume does not exclude the gross tumor volume, brainstem and optic chiasm volumes
