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Table 3 Organs at risk for the 90-patient cohort

From: Sparing of normal tissues with volumetric arc radiation therapy for glioblastoma: single institution clinical experience

  Median (Range)
IMRT VMAT P*
Braina
 Dmean (Gy) 26.7 (12.0–36.5) 27.6 (15.8–36.0) 0.41
 Dmax (Gy) 63.8 (62.6–66.2) 63.5 (62.0–64.9) 0.07
 V30Gy (%) 34.5 (11.4–58.0) 38.0 (19.3–61.5) 0.16
 V60Gy (%) 3.7 (0.7–9.6) 3.3 (1.1–12.1) 0.62
Brainb
 GI50Gy 1.9 (1.5–2.3) 1.9 (1.5–2.4) 0.08
 GI60Gy 5.0 (2.8–31.6) 6.4 (2.3–13.2) 0.05
Brainstem
 Dmean (Gy) 28.7 (7.8–46.3) 19.3 (0.8–39.2) <0.001
 Dmax (Gy) 53.7 (18.2–61.6) 53.2 (2.2–60.4) 0.13
 V30Gy (%) 39.2 (0.0–88.1) 26.1 (0.0–71.4) 0.005
Ipsilateral Hippocampus
 Dmean (Gy) 53.0 (16.0–62.5) 46.8 (1.6–62.3) 0.06
 Dmax (Gy) 60.5 (24.2–64.0) 55.7 (3.2–63.5) 0.12
 D100% (Gy) 31.7 (3.0–59.1) 19.7 (1.0–59.6) 0.03
Contralateral Hippocampus
 Dmean (Gy) 20.3 (10.9–55.9) 22.5 (0.9–55.8) 0.25
 Dmax (Gy) 34.7 (18.3–61.9) 39.3 (1.7–62.8) 0.26
 D100% (Gy) 13.1 (2.1–46.3) 13.4 (0.7–50.8) 0.88
Bilateral Hippocampus
 Dmean (Gy) 35.7 (13.7–57.0) 35.1 (1.3–56.3) 0.79
 Dmax (Gy) 60.5 (24.2–64.0) 56.0 (3.2–63.5) 0.15
 D100% (Gy) 12.3 (2.1–46.3) 11.6 (0.7–47.0) 0.95
Optic Chiasm
 Dmean (Gy) 35.8 (1.3–52.9) 35.7 (1.5–52.5) 0.84
 Dmax (Gy) 51.6 (2.3–55.7) 51.3 (1.8–53.9) 0.52
Ipsilateral Optic Nerve
 Dmean (Gy) 20.9 (0.7–49.7) 20.7 (0.9–47.8) 0.73
 Dmax (Gy) 35.9 (1.1–55.7) 43.6 (1.3–54.5) 0.72
Contralateral Optic Nerve
 Dmean (Gy) 9.9 (0.6–46.4) 12.2 (0.8–44.9) 0.46
 Dmax (Gy) 19.5 (1.0–55.0) 23.6 (1.2–54.7) 0.80
Ipsilateral Cochlea
 Dmean (Gy) 25.6 (3.0–61.9) 5.9 (0.5–48.2) <0.001
 Dmax (Gy) 30.8 (3.6–62.3) 6.8 (0.6–53.7) <0.001
Contralateral Cochlea
 Dmean (Gy) 12.7 (1.7–25.8) 3.2 (0.4–20.0) <0.001
 Dmax (Gy) 15.0 (2.0–29.6) 3.8 (0.4–23.7) <0.001
Ipsilateral Eye
 Dmean (Gy) 3.6 (0.4–24.4) 5.1 (0.6–22.5) 0.08
 Dmax (Gy) 7.9 (1.0–49.6) 15.1 (1.0–46.5) 0.32
Contralateral Eye
 Dmean (Gy) 3.1 (0.4–8.5) 4.0 (0.6–20.9) 0.08
 Dmax (Gy) 7.1 (0.5–40.2) 9.9 (1.0–37.2) 0.07
Ipsilateral Lens
 Dmean (Gy) 2.2 (0.4–5.6) 2.7 (0.5–14.4) 0.18
 Dmax (Gy) 2.6 (0.4–8.3) 3.1 (0.6–16.8) 0.41
Contralateral Lens
 Dmean (Gy) 1.7 (0.3–19.7) 2.4 (0.5–14.3) 0.02
 Dmax (Gy) 2.0 (0.3–31.2) 2.7 (0.6–17.1) 0.05
  1. IMRT intensity modulated radiation therapy, VMAT volumetric arc therapy, D min minimum dose, D mean mean dose, D max maximum dose, D100% maximum dose covering 100% of organ, V XXGy volume receiving XX Gy or more, GI gradient index
  2. *From Wilcoxon-Mann–Whitney rank sum analysis aBrain organ at risk volume excludes the gross tumor volume, brainstem and optic chiasm volumes bBrain volume does not exclude the gross tumor volume, brainstem and optic chiasm volumes