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Table 5 Dosimetric comparison between plans with and without PTV-H, data given as median (range) for each parameter

From: A topology-based method to mitigate the dosimetric uncertainty caused by the positional variation of the boost volume in breast conservative radiotherapy

 

Original plan (without PTV-H)

New plan (with PTV-H)

p value

High variation group patient (BMI ≥ 23.1) with left side breast cancer (N = 14)

 Tumor bed V97% (%)

99.9 (99, 100)

99.9 (97, 100)

 

 Whole breast V97% (%)

96.4 (93.2, 98)

97.1 (95.3, 98.2)

 Ipsilateral lung V5 (%)

27.4 (19.5, 49.1)

28.5 (20, 48.93)

0.002*

 Ipsilateral lung V10 (%)

19.4 (12.23, 38.87)

20.1 (12.5, 38.4)

0.006*

 Ipsilateral lung V20 (%)

15.1 (8.7, 30.6)

15.2 (8.8, 30.5)

0.013*

 Ipsilateral lung mean dose (cGy)

847.4 (549, 1537.5)

889.6 (560, 1549.5)

0.001*

 Heart V25 (%)

2.37 (0.29, 9.13)

2.29 (0.24, 11.1)

0.197

 Heart mean dose (cGy)

251.7 (150.7, 543.8)

250.5 (160.7, 649)

0.158

High variation group patient (BMI ≥ 23.1) with right side breast cancer (N = 10)

 Tumor bed V97% (%)

99.96 (99.3, 99.99)

99.6 (98.9, 100)

 

 Whole breast V97% (%)

97.2 (94.7, 98.4)

97.8 (95.5, 98.7)

 Ipsilateral lung V5 (%)

30.4 (20.3, 35.6)

31 (20.7, 35.8)

0.005*

 Ipsilateral lung V10 (%)

20.5 (12.3, 25.9)

20.74 (12.5, 26.1)

0.005*

 Ipsilateral lung V20 (%)

15.9 (7.6, 20.7)

15.9 (7.5, 21)

0.221

 Ipsilateral lung mean dose (cGy)

887 (502, 1080.5)

902 (500, 1089)

0.007*

 Heart V25 (%)

0 (0, 0)

0 (0, 0)

1

 Heart mean dose (cGy)

44.7 (33.8, 66.4)

49.1 (34.6, 66.5)

0.114

Low variation group patient (BMI < 23.1) with left side breast cancer (N = 15)

 Tumor bed V97% (%)

100 (98, 100)

100 (97.8, 100)

 

 Whole breast V97% (%)

97.1 (91.7, 98)

97.2 (92, 98.9)

 Ipsilateral lung V5 (%)

29.2 (22.4, 36.2)

29.6 (22.6, 32.3)

0.001*

 Ipsilateral lung V10 (%)

21.5 (15.6, 27.5)

21.5 (15.9, 27.6)

0.031*

 Ipsilateral lung V20 (%)

17 (10.9, 21.7)

16.9 (10.9, 21.8)

0.495

 Ipsilateral lung mean dose (cGy)

892.3 (668.6, 1148.7)

909.8 (683.6, 1159)

0.003*

 Heart V25 (%)

1.6 (0.04, 4.66)

1.6 (0.05, 4.86)

0.625

 Heart mean dose (cGy)

218.8 (95, 374.2)

218.8 (95.9, 381)

0.073

Low variation group patient (BMI < 23.1) with right side breast cancer (N = 9)

 Tumor bed V97% (%)

100 (99.9, 100)

100 (99.8, 100)

 

 Whole breast V97% (%)

97.4 (94.2, 98.5)

98 (94.7, 98.5)

 Ipsilateral lung V5 (%)

30.6 (21.6, 38.4)

31.7 (22.2, 39)

0.008*

 Ipsilateral lung V10 (%)

21.6 (14.2, 26.3)

22.3 (14.5, 26.6)

0.008*

 Ipsilateral lung V20 (%)

15.7 (10.4, 19.9)

16.2 (10.7, 19.4)

0.066

 Ipsilateral lung mean dose (cGy)

902.3 (623.7, 1099)

929.1 (639.2, 1111)

0.008*

 Heart V25 (%)

0 (0, 0)

0 (0, 0)

1

 Heart mean dose (cGy)

43.1 (22.8, 53)

43.2 (24, 53.2)

0.05

  1. *p <0.05
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Radiation Oncology

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