The benefit of adjuvant radiotherapy after breast conserving surgery in older patients with low risk breast cancer- a meta-analysis of randomized trials

Table 1 study characteristics

	Fyles et al. NEJM 2004	Hughes et al. CO 2013	Pötter et al. Int J radiation Oncol Biol Phys 2007	Blamey et al. Eur J Cancer 2013	Kunkler Lancet Oncol 2015
Trial design	Multicenter, randomized	Multicenter, randomized	Multicenter, randomized	Multicenter, randomized	Multicenter, randomized
Number of patients recruitment	769 1992–2000	636 1994–1999	869 1996–2004	204 1992–2000	1326 2003–2009
Inclusion criteria: age	≥50 years	≥70 years	≥50 years^a	≥50 years	≥65 years
Tumor diameter	<5 cm	<2 cm	<3 cm	<2 cm	<3 cm
ER/PR positiv	100%	100%	100%	100%	100%
Her-2neu	unknown	unknown	unknown	unknown	Unknown, because this marker was not routinely assessed at the beginning of the trial
Other main inclusion criteria	Postmenopausal status, MO	Postmenopausal status, MO	Postmenopausal status, MO	Postmenopausal status, MO	Postmenopausal status, MO
Breast surgery	lumpectomy	lumpectomy	lumpectomy	Wide local excision	lumpectomy

ISSN: 1748-717X