Fig. 3
From: Influence of autophagy on the efficacy of radiotherapy
Title: For UPR signaling pathway, PERK and IRE1 activate autophagy through endoplasmatic reticulum stress. PERK promotes ATF4 and CHOP, which results in the promotion of ATG gene expression. IRE1 activates JNK, which belongs to the MAPK pathway. JNK promotes autophagy through the inhibition of Bcl-2 and activation of Beclin-1. Legend: Green arrows represent activating or repressing processes for autophagy stimulation and the red arrow represent a repressing process for autophagy inhibition