Fig. 4

Correlating Dose Map with Cytotoxicity: a) ¹⁷⁷Lu Dose Map; b) Distribution of p-H2AX positive cells; Blue = DAPI; Red = p-H2AX immunostain; c) Histogram showing the number of cells that received a given dose of radiation according to the dose map; d) Number of p-H2AX positive cells that received a given dose; e) Percent of p-H2AX positive cells that received a given dose, taken from bins with > 1000 total cells as seen in c. As cells received a higher dose of radiation, a higher percent of those cells stained positive for DNA double-stranded break repair, beginning around 1 Gy over 24 h