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Table 3 Comparison between various metrics in planning phase II. The data are the median and range values of the five patients included into the study. PTV70+PET corresponds to the PTV70 encompassing the PTVPET while PTV70 is the part of the PTV70 outside of the PTVPET. In a similar way, PTV56 is the part of the PTV56 outside of the PTV70

From: Radiation dose escalation based on FDG-PET driven dose painting by numbers in oropharyngeal squamous cell carcinoma: a dosimetric comparison between TomoTherapy-HA and RapidArc

PHASE II

RapidArc

Helical Tomotherapy

p-value

Median

Min - Max

Median

Min - Max

QVH indexes

VQ=0.95 (%)

99.7

99.4–100.0

95.3

92.2–96.4

0.043

VQ=1.05 (%)

0.2

0.0–0.4

2.6

0.7–6.5

0.043

QF (%)

1.5

1.3–1.6

1.9

1.8–2.3

0.043

PTV70+PET

D98% (Gy)

66.4

65.7–67.0

66.6

66.0–67.0

n.s.

D95% (Gy)

67.3

66.8–67.9

67.6

67.0–67.7

n.s.

D50% (Gy)

70.3

70.1–70.5

70.0

69.9–70.3

0.043

D2% (Gy)

79.7

75.2–81.7

79.6

75.6–81.7

n.s.

V95% (%)

97.8

96.2–98.8

98.1

96.8–99.0

n.s.

HI

0.2

0.1–0.2

0.2

0.1–0.2

n.s.

PTV70

D98% (Gy)

66.3

65.6–66.5

66.4

65.9–66.7

n.s.

D95% (Gy)

67.2

66.6–67.5

67.3

66.9–67.5

n.s.

D50% (Gy)

70.1

69.8–70.3

69.9

69.8–70.1

0.042

D2% (Gy)

73.0

72.7–73.4

71.6

71.3–71.9

0.043

V95% (%)

97.6

95.4–98.0

97.7

96.4–98.5

n.s.

V107% (%)

0.0

0.0–0.1

0.0

0.0–0.0

n.s.

HI

0.1

0.1–0.1

0.1

0.1–0.1

0.039

PTV56

D98% (Gy)

53.6

53.2–53.8

53.9

51.6–54.3

n.s.

D95% (Gy)

54.4

54.1–54.5

54.6

53.6–54.9

n.s.

D50% (Gy)

56.7

56.5–57.2

55.9

55.7–56.2

0.043

D2% (Gy)

67.5

67.0–68.1

65.8

65.7–67.2

0.042

V95% (%)

98.7

98.0–99.2

99.0

96.1–99.2

n.s.

V107% (%)

12.0

10.1–20.7

11.0

8.6–14.2

0.043

HI

0.2

0.2–0.3

0.2

0.2–0.3

n.s.

PRV SC

D2% (Gy)

27.8

24.5–29.9

26.4

24.8–28.5

n.s.

PRV BS

D2% (Gy)

22.5

17.2–24.4

21.3

17.9–23.7

n.s.

Ipsilateral parotid

Dmean (Gy)

26.6

24.8–28.9

26.8

25.0–28.3

n.s.

Contralateral parotid

Dmean (Gy)

21.6

19.2–23.9

21.0

20.4–24.7

n.s.

Oral cavity

Dmean (Gy)

28.5

19.4–42.0

28.2

18.1–44.4

n.s.

Oral cavity minus PTV

Dmean (Gy)

18.3

16.6–22.3

19.8

15.8–27.0

n.s.

Lower PCM

Dmean (Gy)

38.2

26.0–47.7

37.5

24.0–50.9

n.s.

Cricophar. muscle

Dmean (Gy)

23.6

14.9–35.2

22.5

13.8–34.7

n.s.

Cervical esophagus

Dmean (Gy)

15.1

12.6–19.7

14.2

10.0–21.4

n.s.

Larynx

Dmean (Gy)

46.1

29.3–54.0

49.6

24.2–54.7

n.s.

Larynx minus PTV

Dmean (Gy)

21.6

17.3–30.5

23.2

17.3–28.8

n.s.

Mandible

D5% (Gy)

58.5

57.0–65.5

59.2

55.8–68.5

n.s.

Conformity index

CI PTV70

1.1

1.0–1.1

1.1

1.0–1.1

n.s.

CI PTV56

1.3

1.3–1.5

1.3

1.2–1.4

n.s.

  1. PCM pharyngeal constrictor muscle