Table 4 Univariate analysis of SVZ-dosimetric data prognostic factors (low dose vs high dose) for time-to-progression (TTP) and overall survival (OS) using various thresholds
From: Subventricular zones: new key targets for glioblastoma treatment
| Â | Without temporal horn (TH-) | With temporal horn (TH+) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | n = | Med TTP (mo) | p | Med OS (mo) | p | n = | Med TTP (mo) | p | Med OS (mo) | p |
Dmean (40Â Gy) | ||||||||||
 iSVZ | ||||||||||
  ≤ 40 Gy | 15 | 5.2 | 0.283 | 18.9 | 0.549 | 10 | 5.2 | 0.727 | 20.3 | 0.659 |
  > 40 Gy | 25 | 6.6 |  | 24.7 |  | 30 | 5.6 |  | 24.7 |  |
 bSVZ | ||||||||||
  ≤ 40 Gy | 30 | 4.6 | 0.023 | 20.7 | 0.198 | 34 | 5.3 | 0.399 | 24.7 | 0.963 |
  > 40 Gy | 10 | 9.4 |  | 22.7 |  | 6 | 9.1 |  | 11.7 |  |
Dmean (43Â Gy) | ||||||||||
 iSVZ | ||||||||||
  ≤ 43 Gy | 17 | 5.3 | 0.529 | 20.3 | 0.392 | 14 | 12.1 | 0.072 | 26.2 | 0.087 |
  > 43 Gy | 23 | 6.4 |  | 25.1 |  | 26 | 4.8 |  | 20.5 |  |
 bSVZ | ||||||||||
  ≤ 43 Gy | 33 | 5.3 | 0.073 | 22.7 | 0.397 | - | - | - | - | - |
  > 43 Gy | 7 | 9.1 |  | 34.2 |  | - | - |  | - |  |
V20Â Gy | ||||||||||
 iSVZ | ||||||||||
  ≤ 84% | 15 | 5.3 | 0.528 | 20.7 | 0.709 | 20 | - | - | - | - |
  > 84% | 25 | 6.4 |  | 24.7 |  | 20 | - |  | - |  |
 bSVZ | ||||||||||
  ≤ 84% | 32 | 5.2 | 0.017 | 22.7 | 0.19 | 39 | - | - | - | - |
  > 84% | 8 | 17.7 |  | 20.3 |  | 1 | - |  | - |  |