Table 1 Patient demographics, disease and treatment characteristics
From: Subventricular zones: new key targets for glioblastoma treatment
Characteristic | n = 43 | V20Gy to bSVZ ≤84% (n = 32) | V20Gy to bSVZ >84% (n = 8) | p |
|---|---|---|---|---|
Age at surgery (years) (median, range) | 59 (25–85) | 60 (30–85) | 64.5 (45–76) | 0.710 |
Gender | 0.222 | |||
 Male | 28 (65.1%) | 19 (59.4%) | 7 (87.5%) |  |
 Female | 15 (34.9%) | 13 (40.6%) | 1 (12.5%) |  |
ECOG performance status at diagnosis | 0.080 | |||
 0–1 | 33 (76.7%) | 28 (87.5%) | 3 (37.5%) |  |
 2–4 | 10 (23.3%) | 4 (12.5%) | 5 (62.5%) |  |
Tumor side | 0.406 | |||
 Right | 29 (67.4%) | 22 (68.8%) | 7 (87.5%) |  |
 Left | 13 (30.2%) | 10 (31.3%) | 1 (12.5%) |  |
 Both | 1 (2.4%) | 0 | 0 |  |
Tumor location | 0.014 | |||
 Frontal | 12 (27.9%) | 5 (15.6%) | 6 (75%) |  |
 Temporal | 18 (41.9%) | 16 (50%) | 1 (12.5%) |  |
 Parietal | 10 (23.3%) | 9 (28.1%) | 1 (12.5%) |  |
 Occipital | 2 (4.7%) | 2 (6.3%) | 0 |  |
 Thalamic | 1 (2.3%) | 0 | 0 |  |
Multilobar lesion | 0.689 | |||
 No | 29 (67.4%) | 20 (62.5%) | 6 (75%) |  |
 Yes | 14 (32.6%) | 12 (37.5%) | 2 (25%) |  |
Tumor SVZ contact | 0.424 | |||
 Yes | 26 (63.4%) | 21 (67.7%) | 4 (50%) |  |
 No | 15 (36.6%) | 10 (32.3%) | 4 (50%) |  |
 Missing | 2 | 1 | 0 |  |
Minimal distance to SVZ (mm) | 0.366 | |||
 Median (range) | 0 (0–27.8) | 0 (0–27.8) | 5.3 (0–24.6) |  |
 Missing | 2 | 1 | 0 |  |
T1 post-gadolinium volume (cm3) | 0.585 | |||
 Median (range) | 40.8 (4.4–151.9) | 40.5 (4.4–94.5) | 46.6 (6.5–151.9) |  |
 Missing | 3 | 1 |  |  |
FLAIR volume (cm3) | 0.290 | |||
 Median (range) | 151.4 (24.8–342.6) | 115.3 (24.8–269) | 194.1 (69.8–342.6) |  |
MGMT status | 0.413 | |||
 Methylated | 14 (35%) | 9 (31%) | 4 (50%) |  |
 Unmethylated | 26 (65%) | 20 (69%) | 4 (50%) |  |
 Unknown | 3 | 3 | 0 |  |
Extent of resection | 0.430 | |||
 GTR/NTR | 19 (44.2%) | 13 (40.6%) | 5 (62.5%) |  |
 STR | 24 (55.8%) | 19 (59.4%) | 3 (37.5%) |  |
Number of cycles of adjuvant temozolomide (median, range) | 6 (1–15) | 3 (1–15) | 5 (2–9) | 0.510 |