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Table 3 Pathological results and tumor response to neoadjuvant treatment (N = 34)b

From: Neoadjuvant FOLFOX chemotherapy combined with radiotherapy followed by radical resection in patients with locally advanced colon cancer

 

No. (%)

ypT

 0

9 (26.4)

 1

0 (0)

 2

5 (14.7)

 3

17 (50.0)

 4

3 (8.9)

ypN

 0

28 (82.4)

 1

5 (14.7)

 2

1 (2.9)

Median number of resected nodesa

11 (3–26)

Median number of involved nodesa

0 (0–6)

Lymph node with extranodal involvement

4 (11.7)

Lymphovascular invasion

 Yes

5 (14.7)

 No

29 (85.3)

Perineural invasion

 Yes

2 (5.9)

 No

32 (94.1)

Tumor differentiation

 Well

2 (5.9)

 Moderately

28 (82.4)

 Poorly

4 (11.7)

Resection margin (CRM)

 Negative

31 (91.2)

 Positive

3 (8.8)

Pathologic complete response

 Yes

9 (26.4)

 No

25 (73.6)

Tumor regression grade

 0

9 (26.4)

 1

11 (32.4)

 2

7 (20.6)

 3

7 (20.6)

ypT0-2 vs. ypT3-4

 ypT0-2

14 (41.2)

 ypT3-4

20 (58.8)

Pathologic T stage

 Downstaging

24 (70.6)

 Stable

10 (29.4)

 Progressive

0 (0)

Pathologic N stage

 Downstaging

31 (91.2)

 Stable

3 (8.8)

 Progressive

0 (0)

Pathologic TN stage

 Downstaging

29 (85.3)

 Stable

5 (14.7)

 Progressive

0 (0)

  1. aMedian (range)
  2. bTwo patients (T4bN2M0 and T4aN2M0) did not receive surgical resection due to unresectable tumor despite chemoradiotherapy
  3. ypT postoperative pathologic tumor stage, ypN postoperative pathologic nodal stage, CRM circuferential resection margin