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Table 5 Evaluation of BMO plans with different biological models

From: An integrated strategy of biological and physical constraints in biological optimization for cervical carcinoma

Biological comparison

Structures

NTCP value

NTCP value

Paired t-test p

Rectum: ar VS. br

Rectum

0.11 ± 0.12ar

0.33 ± 0.19br

<0.01

Bladder

0.14 ± 0.19ab

0.14 ± 0.19ab

-

Rectum: ar VS. cr

Rectum

0.11 ± 0.12ar

0.01 ± 0.02cr

<0.01

Bladder

0.14 ± 0.19ab

0.14 ± 0.19ab

-

Bladder: ab VS. bb

Rectum

0.11 ± 0.12ar

0.11 ± 0.12ar

-

Bladder

0.14 ± 0.19ab

0.00 ± 0.00bb

<0.01

  1. The superscripts of NTCP values denote the different biological models of rectum and bladder which listed in Table 3 used for IMRT optimization. ar: LKB with \( {D}_{50} \) =80Gy, \( \gamma \) =3.9, N = 0.06, M = 0.15 for rectum; br: LKB with \( {D}_{50} \) =81.8Gy, \( \gamma \) =3, N = 0.29, M = 0.22 for rectum; cr: Poisson-LQ with \( {D}_{50} \) =80Gy, \( \gamma \) =2.2, \( \alpha /\beta \) =3Gy, s = 1 for rectum; ab: LKB with \( {D}_{50} \) =62Gy, \( \gamma \) =6, N = 0.13, M = 0.11 for bladder; bb: Poisson-LQ with \( {D}_{50} \) =80Gy, \( \gamma \) =3, \( \alpha /\beta \) =3Gy, s = 0.18 for bladder