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Table 5 Evaluation of BMO plans with different biological models

From: An integrated strategy of biological and physical constraints in biological optimization for cervical carcinoma

Biological comparison Structures NTCP value NTCP value Paired t-test p
Rectum: ar VS. br Rectum 0.11 ± 0.12ar 0.33 ± 0.19br <0.01
Bladder 0.14 ± 0.19ab 0.14 ± 0.19ab -
Rectum: ar VS. cr Rectum 0.11 ± 0.12ar 0.01 ± 0.02cr <0.01
Bladder 0.14 ± 0.19ab 0.14 ± 0.19ab -
Bladder: ab VS. bb Rectum 0.11 ± 0.12ar 0.11 ± 0.12ar -
Bladder 0.14 ± 0.19ab 0.00 ± 0.00bb <0.01
  1. The superscripts of NTCP values denote the different biological models of rectum and bladder which listed in Table 3 used for IMRT optimization. ar: LKB with \( {D}_{50} \) =80Gy, \( \gamma \) =3.9, N = 0.06, M = 0.15 for rectum; br: LKB with \( {D}_{50} \) =81.8Gy, \( \gamma \) =3, N = 0.29, M = 0.22 for rectum; cr: Poisson-LQ with \( {D}_{50} \) =80Gy, \( \gamma \) =2.2, \( \alpha /\beta \) =3Gy, s = 1 for rectum; ab: LKB with \( {D}_{50} \) =62Gy, \( \gamma \) =6, N = 0.13, M = 0.11 for bladder; bb: Poisson-LQ with \( {D}_{50} \) =80Gy, \( \gamma \) =3, \( \alpha /\beta \) =3Gy, s = 0.18 for bladder