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Table 4 Evaluation of DVO plans, BMO plans and ISO plans

From: An integrated strategy of biological and physical constraints in biological optimization for cervical carcinoma

Structures

Parameters

DVO

BMO

ISO

P1

P2

P3

PTV

D98 (Gy)

54.57 ± 0.46

53.42 ± 0.36

54.18 ± 0.38

<0.01

<0.01

<0.01

D2 (Gy)

58.82 ± 0.22

58.72 ± 0.28

58.89 ± 0.26

0.27

0.12

0.18

V95 (%)

99.13 ± 0.82

96.79 ± 0.81

98.31 ± 0.91

<0.01

<0.01

<0.01

HI

0.08 ± 0.01

0.10 ± 0.01

0.09 ± 0.01

<0.01

<0.01

<0.01

CI

0.82 ± 0.04

0.71 ± 0.05

0.76 ± 0.04

<0.01

<0.01

<0.01

TCP

15.39 ± 0.06

15.55 ± 0.58

15.39 ± 0.05

0.22

0.23

0.97

OAR

Rectum

V20 (%)

97.55 ± 3.41

95.21 ± 6.98

92.66 ± 6.36

0.10

<0.01

<0.01

V30 (%)

63.43 ± 10.06

69.67 ± 12.80

60.29 ± 12.76

0.01

<0.01

0.17

V40 (%)

26.46 ± 10.90

24.35 ± 12.44

24.24 ± 10.14

0.13

0.93

0.07

V50 (%)

6.16 ± 5.63

4.35 ± 5.82

7.62 ± 10.66

<0.01

0.02

0.31

Dmax (Gy)

56.55 ± 2.06

54.29 ± 2.93

56.00 ± 2.01

<0.01

<0.01

0.13

Dmean (Gy)

34.62 ± 2.81

34.49 ± 2.68

33.49 ± 2.59

0.66

<0.01

<0.01

NTCP

0.19 ± 0.17ar

0.11 ± 0.12ar

0.14 ± 0.13ar

<0.01

<0.01

<0.01

Bladder

V20 (%)

95.35 ± 4.50

93.90 ± 7.13

91.29 ± 7.79

0.35

<0.01

0.03

V30 (%)

62.10 ± 8.71

63.32 ± 8.90

58.06 ± 8.12

0.47

<0.01

<0.01

V40 (%)

29.08 ± 7.07

30.27 ± 7.29

29.68 ± 6.71

0.25

0.28

0.54

V50 (%)

9.79 ± 5.96

8.86 ± 6.44

9.83 ± 6.80

0.07

0.02

0.93

Dmax (Gy)

58.95 ± 1.38

58.22 ± 1.75

58.63 ± 1.72

<0.01

0.09

0.09

Dmean (Gy)

34.29 ± 2.19

34.65 ± 2.22

33.92 ± 2.13

0.15

<0.01

0.12

NTCP

0.18 ± 0.20ab

0.14 ± 0.19 ab

0.16 ± 0.20ab

0.03

0.15

<0.01

Small bowel

V20 (%)

52.02 ± 8.45

51.37 ± 9.77

51.77 ± 8.90

0.44

0.35

0.41

V45 (%)

0.87 ± 1.48

0.83 ± 1.62

0.84 ± 1.79

0.32

0.26

0.30

NTCP

0.94 ± 1.53

0.89 ± 1.74

0.90 ± 1.88

0.39

0.23

0.28

B-P

 

Dmax (Gy)

57.59 ± 3.05

58.39 ± 1.88

58.04 ± 2.41

0.17

0.27

0.36

  1. The p value p1, p2, p3 were represented of the p value between DVO and BMO, BMO and ISO, DVO and ISO, respectively. The superscripts of NTCP values denote the biological models of rectum and bladder which listed in Table 3 used for IMRT optimization. ar: LKB with \( {D}_{50} \) =80Gy, \( \gamma \) =3.9, N = 0.06, M = 0.15 for rectum; ab: LKB with \( {D}_{50} \) =62Gy, \( \gamma \) =6, N = 0.13, M = 0.11 for bladder