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Table 4 Evaluation of DVO plans, BMO plans and ISO plans

From: An integrated strategy of biological and physical constraints in biological optimization for cervical carcinoma

Structures Parameters DVO BMO ISO P1 P2 P3
PTV D98 (Gy) 54.57 ± 0.46 53.42 ± 0.36 54.18 ± 0.38 <0.01 <0.01 <0.01
D2 (Gy) 58.82 ± 0.22 58.72 ± 0.28 58.89 ± 0.26 0.27 0.12 0.18
V95 (%) 99.13 ± 0.82 96.79 ± 0.81 98.31 ± 0.91 <0.01 <0.01 <0.01
HI 0.08 ± 0.01 0.10 ± 0.01 0.09 ± 0.01 <0.01 <0.01 <0.01
CI 0.82 ± 0.04 0.71 ± 0.05 0.76 ± 0.04 <0.01 <0.01 <0.01
TCP 15.39 ± 0.06 15.55 ± 0.58 15.39 ± 0.05 0.22 0.23 0.97
OAR Rectum V20 (%) 97.55 ± 3.41 95.21 ± 6.98 92.66 ± 6.36 0.10 <0.01 <0.01
V30 (%) 63.43 ± 10.06 69.67 ± 12.80 60.29 ± 12.76 0.01 <0.01 0.17
V40 (%) 26.46 ± 10.90 24.35 ± 12.44 24.24 ± 10.14 0.13 0.93 0.07
V50 (%) 6.16 ± 5.63 4.35 ± 5.82 7.62 ± 10.66 <0.01 0.02 0.31
Dmax (Gy) 56.55 ± 2.06 54.29 ± 2.93 56.00 ± 2.01 <0.01 <0.01 0.13
Dmean (Gy) 34.62 ± 2.81 34.49 ± 2.68 33.49 ± 2.59 0.66 <0.01 <0.01
NTCP 0.19 ± 0.17ar 0.11 ± 0.12ar 0.14 ± 0.13ar <0.01 <0.01 <0.01
Bladder V20 (%) 95.35 ± 4.50 93.90 ± 7.13 91.29 ± 7.79 0.35 <0.01 0.03
V30 (%) 62.10 ± 8.71 63.32 ± 8.90 58.06 ± 8.12 0.47 <0.01 <0.01
V40 (%) 29.08 ± 7.07 30.27 ± 7.29 29.68 ± 6.71 0.25 0.28 0.54
V50 (%) 9.79 ± 5.96 8.86 ± 6.44 9.83 ± 6.80 0.07 0.02 0.93
Dmax (Gy) 58.95 ± 1.38 58.22 ± 1.75 58.63 ± 1.72 <0.01 0.09 0.09
Dmean (Gy) 34.29 ± 2.19 34.65 ± 2.22 33.92 ± 2.13 0.15 <0.01 0.12
NTCP 0.18 ± 0.20ab 0.14 ± 0.19 ab 0.16 ± 0.20ab 0.03 0.15 <0.01
Small bowel V20 (%) 52.02 ± 8.45 51.37 ± 9.77 51.77 ± 8.90 0.44 0.35 0.41
V45 (%) 0.87 ± 1.48 0.83 ± 1.62 0.84 ± 1.79 0.32 0.26 0.30
NTCP 0.94 ± 1.53 0.89 ± 1.74 0.90 ± 1.88 0.39 0.23 0.28
B-P   Dmax (Gy) 57.59 ± 3.05 58.39 ± 1.88 58.04 ± 2.41 0.17 0.27 0.36
  1. The p value p1, p2, p3 were represented of the p value between DVO and BMO, BMO and ISO, DVO and ISO, respectively. The superscripts of NTCP values denote the biological models of rectum and bladder which listed in Table 3 used for IMRT optimization. ar: LKB with \( {D}_{50} \) =80Gy, \( \gamma \) =3.9, N = 0.06, M = 0.15 for rectum; ab: LKB with \( {D}_{50} \) =62Gy, \( \gamma \) =6, N = 0.13, M = 0.11 for bladder