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Table 2 ESCALOX - trial Dose constraints for Organs at Risk (OAR)

From: Do selective radiation dose escalation and tumour hypoxia status impact the loco-regional tumour control after radio-chemotherapy of head & neck tumours? The ESCALOX protocol

OAR

Necessity for planning

accepted dose [EQD2]

Spinal cord

(PRV: Myelon + 5 mm)

Mandatory

Dmax < 50 Gy2 or

No more than 1 cm3 > 45 Gy2

Brachial plexus

Mandatory

60 Gy2

Brainstem

Mandatory

Dmax < 54 Gy2 or no more than 1 cm3 > 54 Gy2

Optical nerve

Mandatory

Dmax < 54 Gy2

Mandible

Recommended

Dmax < 70 Gy2 or no more than 1 cm3 > 70 Gy2

Glottis (outside PTV)

Recommended

2/3 < 50 Gy2; Dmean < 45Gy2

Gl. parotis

Recommended

Dmean < 26 Gy2; D50 < 30 Gy2

20 cm3 of both < 20 Gy2