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Table 4 Published series of local control for patients with brain metastases from gastrointestinal primaries

From: Clinical outcomes of gastrointestinal brain metastases treated with radiotherapy

Study

Year

Number of patients

Number of tumors

Treatment

Previous cranial RT

LC at last follow-up

Median radiographic follow-up

Median OS in months

Primary malignancy

Local Progression definition

Tumor volume

Adeno- carcinoma

Trifiletti et al. [13]

2015

86

 

GKS

19.80%

94%

4.6 months (mean 7.7 months)

6.2

GI

Tumors with a volume increase of 10%

mean 3.7 (0.7 ml median)

59.30%

Matsunaga et al. [24]

2011

152

616

GKS

6%

91%

3.0 months (mean 6.4 months)

6

Colorectal

Tumors with an increase greater than 25% in maximum diameter

mean 2.0 cm3 (0.004–10.0 cm3)

“almost all”

Da Silva et al. [9]

2009

40

118

GKS

47.50%

91%

6.7

GI

Tumors with a volume increase of > 15%

mean 4.3 cm3 (0.01–35)

Current Series

2016

23

28

CK

7.14%

64.30%

3.9 months (mean 6.3 months)

5.2

GI

Increase in tumor size as determined by neuroradiologist

mean 12.1 cm3 (0.2–95.1 cm3)

100%

  1. Abbreviations: RT radiation therapy, OS overall survival, GKS Gamma Knife Surgery, GI gastrointestinal