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Table 4 Published series of local control for patients with brain metastases from gastrointestinal primaries

From: Clinical outcomes of gastrointestinal brain metastases treated with radiotherapy

Study Year Number of patients Number of tumors Treatment Previous cranial RT LC at last follow-up Median radiographic follow-up Median OS in months Primary malignancy Local Progression definition Tumor volume Adeno- carcinoma
Trifiletti et al. [13] 2015 86   GKS 19.80% 94% 4.6 months (mean 7.7 months) 6.2 GI Tumors with a volume increase of 10% mean 3.7 (0.7 ml median) 59.30%
Matsunaga et al. [24] 2011 152 616 GKS 6% 91% 3.0 months (mean 6.4 months) 6 Colorectal Tumors with an increase greater than 25% in maximum diameter mean 2.0 cm3 (0.004–10.0 cm3) “almost all”
Da Silva et al. [9] 2009 40 118 GKS 47.50% 91% 6.7 GI Tumors with a volume increase of > 15% mean 4.3 cm3 (0.01–35)
Current Series 2016 23 28 CK 7.14% 64.30% 3.9 months (mean 6.3 months) 5.2 GI Increase in tumor size as determined by neuroradiologist mean 12.1 cm3 (0.2–95.1 cm3) 100%
  1. Abbreviations: RT radiation therapy, OS overall survival, GKS Gamma Knife Surgery, GI gastrointestinal