From: Clinical outcomes of gastrointestinal brain metastases treated with radiotherapy
Study | Year | Number of patients | Number of tumors | Treatment | Previous cranial RT | LC at last follow-up | Median radiographic follow-up | Median OS in months | Primary malignancy | Local Progression definition | Tumor volume | Adeno- carcinoma |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Trifiletti et al. [13] | 2015 | 86 | GKS | 19.80% | 94% | 4.6 months (mean 7.7 months) | 6.2 | GI | Tumors with a volume increase of 10% | mean 3.7 (0.7 ml median) | 59.30% | |
Matsunaga et al. [24] | 2011 | 152 | 616 | GKS | 6% | 91% | 3.0 months (mean 6.4 months) | 6 | Colorectal | Tumors with an increase greater than 25% in maximum diameter | mean 2.0 cm3 (0.004–10.0 cm3) | “almost all” |
Da Silva et al. [9] | 2009 | 40 | 118 | GKS | 47.50% | 91% | – | 6.7 | GI | Tumors with a volume increase of > 15% | mean 4.3 cm3 (0.01–35) | – |
Current Series | 2016 | 23 | 28 | CK | 7.14% | 64.30% | 3.9 months (mean 6.3 months) | 5.2 | GI | Increase in tumor size as determined by neuroradiologist | mean 12.1 cm3 (0.2–95.1 cm3) | 100% |