Clinical outcomes of gastrointestinal brain metastases treated with radiotherapy

Radiation Oncology

Table 3 Multivariate analysis for overall survival, initial site control and new site control

Characteristic	HR (95% CI)	P-value
Overall survival
Age	0.99 (0.95–1.02)	0.451
ECOG	1.63 (0.69–3.86)	0.263
>2 brain metastases	0.53 (0.12–2.25)	0.388
Active extracranial disease	3.02 (0.62–14.79)	0.173
Intracranial Surgery prior to RT	0.62 (0.24–1.61)	0.326
Treatment WBRT	1.39 (0.45–4.22)	0.566
Initial site control
Total Dose	0.69 (0.31–1.55)	0.372
Treatment WBRT	1.95 (0.68–5.6)	0.212
Intracranial Surgery prior to RT	0.47 (0.16–1.36)	0.164
New site control
Total Dose	3.98 (1.13–14.07)	0.032*
Treatment WBRT	0.05 (0.01–0.35)	0.002*
Active extracranial disease	11.4 (1.54–84.52)	0.017*

Abbreviations: CI confidence interval, HR hazard ratio, ECOG Eastern Cooperative Oncology group
Statistically significant results indicated by *

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