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Table 3 The result of multivariate analysis of significative potential prognostic factors associated with overall survival by using univariate analysis

From: Is pulmonary artery a dose-limiting organ at risk in non-small cell lung cancer patients treated with definitive radiotherapy?

 

Univariate

Multivariate

 

Variables

P value

P value

HR

95% CI

Categorical Variables

CCI

0.00001

0.00001

1.816

1.386–2.378

T-stage

0.0004

0.0001

3.160

1.944–5.138

N-stage

0.007

0.001

1.907

1.315–2.767

Clinical stage

0.001

0.493

0.697

0.248–1.96

PA invasion grade

0.028

0.0001

2.172

1.467–3.216

Continuous Variables

KPS

0.001

0.043

0.934

0.886–0.936

GTV

0.015

0.066

0.986

0.975–0.997

CTV

0.045

0.07

1.01

1.003–1.017

PTV

0.081

0.203

0.998

0.995–1.001

PA V10

0.099

0.698

0.275

0–16.913

PA V15

0.098

0.792

0.309

0–15.602

PA V20

0.084

0.678

1.691

0–4.357

PA V25

0.094

0.468

0.022

0–6.387

PA V30

0.002

0.553

8.474

0.007–9.855

PA V35

0.001

0.111

2.367

0.271–2.967

PA V40

0.001

0.043

2.113

1.014–4.936

PA V45

0.0004

0.0001

2.660

1.089–5.717

PA V50

0.001

0.0001

1.203

0.062–2.056

PA V55

0.002

0.05

1.489

0.098–2.096

PA V60

0.005

0.191

0.076

0.002–3.621

PA V65

0.027

0.149

0.069

0.002–2.598

H V30

0.062

0.148

0

0–4.075

H V35

0.059

0.227

1.725

0–9.681

H V40

0.035

0.755

0.001

0–5.625

H V45

0.092

0.923

5.765

0–12.916

  1. CCI Charlson comorbidity index, KPS karnofsky performance status, GTV gross tumor volume, CTV clinical target volume, PTV planning target volume, D95 minimum dose to 95% volume of targets, PA pulmonary artery, PA V5, 10–70: the percentage of PA volume receiving 5,10 to 70Gy, PA max the maximum dose to PA, PA mean the mean dose to PA, H V5,10-75: the percentage of heart volume receiving 5, 10 to 70Gy, H max the maximum dose to heart, H mean the mean dose to heart