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Table 3 The result of multivariate analysis of significative potential prognostic factors associated with overall survival by using univariate analysis

From: Is pulmonary artery a dose-limiting organ at risk in non-small cell lung cancer patients treated with definitive radiotherapy?

  Univariate Multivariate
  Variables P value P value HR 95% CI
Categorical Variables CCI 0.00001 0.00001 1.816 1.386–2.378
T-stage 0.0004 0.0001 3.160 1.944–5.138
N-stage 0.007 0.001 1.907 1.315–2.767
Clinical stage 0.001 0.493 0.697 0.248–1.96
PA invasion grade 0.028 0.0001 2.172 1.467–3.216
Continuous Variables KPS 0.001 0.043 0.934 0.886–0.936
GTV 0.015 0.066 0.986 0.975–0.997
CTV 0.045 0.07 1.01 1.003–1.017
PTV 0.081 0.203 0.998 0.995–1.001
PA V10 0.099 0.698 0.275 0–16.913
PA V15 0.098 0.792 0.309 0–15.602
PA V20 0.084 0.678 1.691 0–4.357
PA V25 0.094 0.468 0.022 0–6.387
PA V30 0.002 0.553 8.474 0.007–9.855
PA V35 0.001 0.111 2.367 0.271–2.967
PA V40 0.001 0.043 2.113 1.014–4.936
PA V45 0.0004 0.0001 2.660 1.089–5.717
PA V50 0.001 0.0001 1.203 0.062–2.056
PA V55 0.002 0.05 1.489 0.098–2.096
PA V60 0.005 0.191 0.076 0.002–3.621
PA V65 0.027 0.149 0.069 0.002–2.598
H V30 0.062 0.148 0 0–4.075
H V35 0.059 0.227 1.725 0–9.681
H V40 0.035 0.755 0.001 0–5.625
H V45 0.092 0.923 5.765 0–12.916
  1. CCI Charlson comorbidity index, KPS karnofsky performance status, GTV gross tumor volume, CTV clinical target volume, PTV planning target volume, D95 minimum dose to 95% volume of targets, PA pulmonary artery, PA V5, 10–70: the percentage of PA volume receiving 5,10 to 70Gy, PA max the maximum dose to PA, PA mean the mean dose to PA, H V5,10-75: the percentage of heart volume receiving 5, 10 to 70Gy, H max the maximum dose to heart, H mean the mean dose to heart