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Table 2 Clinicopathologic characteristic

From: Is pulmonary artery a dose-limiting organ at risk in non-small cell lung cancer patients treated with definitive radiotherapy?

Characteristic Number (%) Characteristic Number (%)
Age (years)   RT modality  
 Median (range) 60 (39–85) RT alone 55 (39%)
  < 60 72 (5.1) concurrent CRT 47 (33.3%)
  ≥ 60 69 (48.9) sequential CRT 39 (27.7%)
Gender   Tumor stage  
 Male 97 (68.8%) T1 26 (18.4%)
 Female 44 (31.2%) T2 46 (32.6%)
KPS (70–100)   T3 38 (27%)
 70–80 5 (3.5%) T4 31 (22%)
 80–90 28 (19.9%) Lymph nodes stage  
 90–100 108 (76.6) N0 42(29.8%)
Smoking   N1 48 (34%)
 No 68 (48.2%) N2 32 (22.7%)
 Yes 73 (51.8%) N3 19 (13.5%)
Weight loss (%)   Clinical stage  
 Median (range) 3 (0–10) I 5 (3.5%)
  ≤ 3% 72 (51.1) II 47 (33.3%)
  > 3%-10% 69 (48.9) IIIA 62 (44%)
COPD   IIIB 27 (19.1%)
 No 130 (92.2%) PA invasion grade  
 Yes 11 (7.8%) Grade 0 49(34.8%)
CVD   Grade 1 36(25.5%)
 No 108 (76.6%) Grade 2 37(26.2%)
 Yes 33 (23.4%) Grade 3 19(13.5%)
Hypertension   Target volume (cc) median (range)  
 No 109 (77.3%)
 Yes 32 (22.7%) GTV 43.6 (9–400.9)
CCI   CTV 92.2 (12.56–843.6)
 Median (range) 3 (0–7) PTV 213.7 (23.5–1025.5)
  < 3 62 (44.0%) D95 to targets (Gy) median (range)  
  ≥ 3 79 (56.0%)
Tumor location   D95 to GTV 64.9 (48.1–74.0)
 Central 116 (82.3%) D95 to CTV 63.1 (46.4–71.9)
 Peripheral 25 (17.7%) D95 to PTV 60.1 (45.6–69.9)
Pathology   Dmax to PA (Gy)  
 Adenocarcinoma 71 (50.3%) Median (range) 65.8 (0.6–76.2)
 Squamous 61 (43.3%) Dmean to PA (Gy)  
 Large-cell & NOS 9 (6.4%) Median (range) 37.9 (0–71.3)
RT technique   Dmax to Heart (Gy)  
 IMRT 52 (36.9%) Median (range) 56 (0.2–65.7)
 3DCRT 89 (63.1%) Dmean to Heart (Gy)  
RT dose (Gy)   Median (range) 5.2 (0–34.9)
 Median (range) 66 (60–76)   
  < 66 62 (44.0%)   
  ≥ 66 79 (56.0%)   
  1. KPS Karnofsky performance status, COPD chronic obstructive pulmonary disease, CVD Cardiac vascular disease, CCI Charlson comorbidity index, NOS NSCLC not otherwise specified, IMRT intensity modulated radiation therapy, 3DCRT three-dimensional conformal radiation therapy, RT radiotherapy, Chemo Chemotherapy, GTV gross tumor volume, CTV clinical target volume, PTV planning target volume, D95 minimum dose to 95% volume of targets, PA pulmonary artery, cc cubic centimeter, Gy gray, Dmax Maximum dose, Dmean Mean dose