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Table 2 Clinicopathologic characteristic

From: Is pulmonary artery a dose-limiting organ at risk in non-small cell lung cancer patients treated with definitive radiotherapy?

Characteristic

Number (%)

Characteristic

Number (%)

Age (years)

 

RT modality

 

 Median (range)

60 (39–85)

RT alone

55 (39%)

  < 60

72 (5.1)

concurrent CRT

47 (33.3%)

  ≥ 60

69 (48.9)

sequential CRT

39 (27.7%)

Gender

 

Tumor stage

 

 Male

97 (68.8%)

T1

26 (18.4%)

 Female

44 (31.2%)

T2

46 (32.6%)

KPS (70–100)

 

T3

38 (27%)

 70–80

5 (3.5%)

T4

31 (22%)

 80–90

28 (19.9%)

Lymph nodes stage

 

 90–100

108 (76.6)

N0

42(29.8%)

Smoking

 

N1

48 (34%)

 No

68 (48.2%)

N2

32 (22.7%)

 Yes

73 (51.8%)

N3

19 (13.5%)

Weight loss (%)

 

Clinical stage

 

 Median (range)

3 (0–10)

I

5 (3.5%)

  ≤ 3%

72 (51.1)

II

47 (33.3%)

  > 3%-10%

69 (48.9)

IIIA

62 (44%)

COPD

 

IIIB

27 (19.1%)

 No

130 (92.2%)

PA invasion grade

 

 Yes

11 (7.8%)

Grade 0

49(34.8%)

CVD

 

Grade 1

36(25.5%)

 No

108 (76.6%)

Grade 2

37(26.2%)

 Yes

33 (23.4%)

Grade 3

19(13.5%)

Hypertension

 

Target volume (cc)

median (range)

 

 No

109 (77.3%)

 Yes

32 (22.7%)

GTV

43.6 (9–400.9)

CCI

 

CTV

92.2 (12.56–843.6)

 Median (range)

3 (0–7)

PTV

213.7 (23.5–1025.5)

  < 3

62 (44.0%)

D95 to targets (Gy)

median (range)

 

  ≥ 3

79 (56.0%)

Tumor location

 

D95 to GTV

64.9 (48.1–74.0)

 Central

116 (82.3%)

D95 to CTV

63.1 (46.4–71.9)

 Peripheral

25 (17.7%)

D95 to PTV

60.1 (45.6–69.9)

Pathology

 

Dmax to PA (Gy)

 

 Adenocarcinoma

71 (50.3%)

Median (range)

65.8 (0.6–76.2)

 Squamous

61 (43.3%)

Dmean to PA (Gy)

 

 Large-cell & NOS

9 (6.4%)

Median (range)

37.9 (0–71.3)

RT technique

 

Dmax to Heart (Gy)

 

 IMRT

52 (36.9%)

Median (range)

56 (0.2–65.7)

 3DCRT

89 (63.1%)

Dmean to Heart (Gy)

 

RT dose (Gy)

 

Median (range)

5.2 (0–34.9)

 Median (range)

66 (60–76)

  

  < 66

62 (44.0%)

  

  ≥ 66

79 (56.0%)

  
  1. KPS Karnofsky performance status, COPD chronic obstructive pulmonary disease, CVD Cardiac vascular disease, CCI Charlson comorbidity index, NOS NSCLC not otherwise specified, IMRT intensity modulated radiation therapy, 3DCRT three-dimensional conformal radiation therapy, RT radiotherapy, Chemo Chemotherapy, GTV gross tumor volume, CTV clinical target volume, PTV planning target volume, D95 minimum dose to 95% volume of targets, PA pulmonary artery, cc cubic centimeter, Gy gray, Dmax Maximum dose, Dmean Mean dose