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Table 3 Survival times of F98 glioma bearing rats following i.c. delivery of BPA and ACBC-BSH by iv or CED

From: Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma

Agent/Route

Survival Time

%ILSb

Group

na

Mean ± SD

Median

Range

Median

ACBC-BSH/CED + BPA/iv

6

44.3

±

8.0

42.0

38–60

59.2

ACBC-BSH/CED

7

37.0

±

5.2

38.0

31–44

36.0

BPA/iv

5

37.4

±

2.6

37.0

34–40

37.5

Irradiated Controls

5

29.8

±

1.9

30.0

27–32

9.6

Untreated Controls

6

27.2

±

2.4

26.5

25–31

-

  1. ACBC α-aminocyclobutane-1-carboxylic acid, CED convection-enhanced delivery, SD standard deviation, BPA p-boronphenylalanine, BSH dodecaboranethiol, iv intravenous
  2. an is the number of animals per group
  3. bPercent increace life span(%ILS) was defined relative to the mean survival times of untreated controls