|  |  |  | Boron concentrations ± SD(μg10B/g) | Physical doseb (Gy) | Equivalent dosec (Gy-Eq) |
|---|
Agent | Route | Timea(h) | Brain | Tumor | Brain | Tumor | Brain | Tumor |
|---|
ACBC-BSH | CED | 1 | 1.5 | ± | 1.3 | 21.1 | ± | 3.3 | 1.1 | 3.7 | - | - |
BPA | iv | 1 | 3.0 | ± | 0.6 | 19.7 | ± | 1.4 | 1.3 | 3.5 | 2.2 | 11.7 |
Irradiated Controls | - | - | 0 | ± | 0 | 0 | ± | 0 | 0.9 | 0.9 | - | - |
Untreated Controls | - | - | 0 | ± | 0 | 0 | ± | 0 | 0 | 0 | 0 | 0 |
-
D
B
Boron dose, D
N
neutron dose, D
H
hydrogen dose, D
γ
gamm-ray dose
- CBEB is from CBE(Compound Biological Effectiveness) for DB and, in the case of BPA, this value is 3.8 for the tumor tissue and 0.9 for the normal brain
- RBEN is from RBE(Relative Biological Effectiveness) for DN and this value is 3.0
- RBEH is from RBE(Relative Biological Effectiveness) for DH and this value is 3.0
-
aTime to euthanize rats after boron compound administration
-
bPhysical dose estimates include contributions from gamma photons,10B(n,α)7Li, 14 N(n,p)14C, and 1H(n,n)1H reactions
-
cEquivalent dose is a value calculated using the DB x CBEB + DN x RBEN + DH x RBEH + Dγ
