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Fig. 3 | Radiation Oncology

Fig. 3

From: Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma

Fig. 3

a Boron concentration of F98 glioma 24 h after incubation in media including 1 mM of each boron compounds. The boron concentrations of tumor cells were significantly higher in the ACBC-BSH than in the BSH (1.97 ± 0.2 μg B/107 cells and 0.86 ± 0.1 μg B/107 cells). The boron concentrations of tumor cells were the highest in the BPA. *, P = 0.033; **, P = 0.0014. b Boron concentrations in a tumor in F98 glioma bearing rats, when we administrated BPA, BSH, and ACBC-BSH at the dose of 12 mg 10B/kg by i.v. ***, P < 0.05. c Boron concentrations in a tumor in F98 glioma bearing rats, when we administrated BPA, BSH, and ACBC-BSH at the dose of 1.2 mg 10B/kg by CED. ***, P < 0.05. d Product values of the intratumoral 10B concentration and the tumor/normal tissues 10B ratio; [10B concentration in a tumor] x [Tumor/Blood 10B ratio]. e Product values of the intratumoral 10B concentration and the tumor/normal tissues 10B ratio; [10B concentration in a tumor] x [Tumor/Brain 10B ratio]

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Radiation Oncology

ISSN: 1748-717X

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