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Table 3 Previously published rates of toxicity following prostate SBRT

From: Toxicity and quality of life report of a phase II study of stereotactic body radiotherapy (SBRT) for low and intermediate risk prostate cancer

Study

n

Dose/Fractions

Timepoint

Genitourinary Toxicity

Gastrointestinal Toxicity

Grade 2

≥ Grade 3

Grade 2

≥ Grade 3

Madsen [10]

40

33.5/5

Within or after 1 month

Acute 20.5%

Acute 2.5%

Acute 13%

Acute 0%

Late 20%

Late 0%

Late 7.5%

Late %

Tang [12]

30

35/5

≤6 months

13%

0%

7%

0%

King [9]

41

36.25/5

≥6 months

24%

5%

15%

0%

McBride [11]

34

37.5–36.25/5

Within or after 3 months

Acute 19%

Acute 0%

Acute 7%

Acute 0%

Late 17%

Late 2%

Late 7%

Late 5%

Hannan [8]

91

45–50/5

Within or after 9 months

Acute 22%

Acute 0%

Acute 20.9%

Acute 2.2%

Late 20.9%

Late 5.5%

Late 13.2%

Late 6.6%

Alonghi [7]

40

35/5

Within or after 6 months

Acute 40%

Acute 0%

Acute 10%

Acute 0%

Late 2.5%

Late 0%

Late 0%

Late 0%

  1. Reported toxicity of previously published phase I and/or II trials of SBRT for prostate cancer; n = number of patients on trial, dose is reported in Gy