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Table 1 Selected studies of Intraoperative Radiotherapy in resected pancreatic cancer

From: Intraoperative radiation therapy (IORT) in pancreatic cancer

Studies Number IORT Dose (Gy) EBRT Operative mortality Peri-/ postoperative complications Local recurrence Overall survival (Median)
Sindelar et al. [33] 24 20 100%     
12 Surgery and EBRT      100% 12 month
12 Surgery and IORT or EBRT      33% 18 month
Zerbi et al. [34] 90 12.5–20 36%     
47 Surgery    2.1% 23.4% 56,4% 12 month
43 Surgery and IORT    2.3% 23.2% 26% 19 month
Alfieri et al. [35] 46 10 67%     
20 Surgery    8% 43% 71.2 10.8 month
26 Surgery and IORT    9% 57% 41.6% 14.3 month
Reni et al. [36] 203 10–25 28%    Median time to  
76 Surgery    4% 45% local failure 12 month
127 Surgery and IORT    5% 39% 11 month
14 month
15.5 month
Ogawa et al. [37] 210 30% 63%    16.3% 19.1 month
All patients Surgery and IORT       
Valentini et al. [38] 270
All patients surgery and IORT
7.5–25 63%    Median time to local failure 15 month 19 month
Showalter et al. [47] 99 10–20      
46 Surgery + − EBRT   66%   40% 39% 19.2 month
37 surgery IORT + − EBRT   74%   46% 21% 21 month