Intraoperative radiation therapy (IORT) in pancreatic cancer

Radiation Oncology

Table 1 Selected studies of Intraoperative Radiotherapy in resected pancreatic cancer

Studies	Number	IORT Dose (Gy)	EBRT	Operative mortality	Peri-/ postoperative complications	Local recurrence	Overall survival (Median)
Sindelar et al. [33]	24	20	100%
	12 Surgery and EBRT					100%	12 month
	12 Surgery and IORT or EBRT					33%	18 month
Zerbi et al. [34]	90	12.5–20	36%
	47 Surgery			2.1%	23.4%	56,4%	12 month
	43 Surgery and IORT			2.3%	23.2%	26%	19 month
Alfieri et al. [35]	46	10	67%
	20 Surgery			8%	43%	71.2	10.8 month
	26 Surgery and IORT			9%	57%	41.6%	14.3 month
Reni et al. [36]	203	10–25	28%			Median time to
	76 Surgery			4%	45%	local failure	12 month
	127 Surgery and IORT			5%	39%	11 month 14 month	15.5 month
Ogawa et al. [37]	210	30%	63%			16.3%	19.1 month
Ogawa et al. [37]	All patients Surgery and IORT
Valentini et al. [38]	270 All patients surgery and IORT	7.5–25	63%			Median time to local failure 15 month	19 month
Showalter et al. [47]	99	10–20
	46 Surgery + − EBRT		66%		40%	39%	19.2 month
	37 surgery IORT + − EBRT		74%		46%	21%	21 month

ISSN: 1748-717X