Intraoperative radiation therapy for colon and rectal cancers: a clinical review

Radiation Oncology

Table 5 Disease control and survival with IOERT for locally recurrent rectal cancer in association with R2 resection. Results of selected series

Study	Years	# Patients	EBRT dose, Gy	IORT dose, Gy	5-year LC	5-year DM	5-year OS
Lindel, MGH [31]	1978–1997	15	50.4^a	15–20	12%	-	13%
Eble, Heidelberg [33]^b	1991–1995	8	41.4	10–20	60%	75%	25%^c
Dresen, Eindhoven [34]	1994–2006	29	50.4^d	15–17.5	29%	71%	24%
Haddock, Mayo Clinic [19]	1981–2008	156	50.4^e	20	49%	73%	16%

Abbreviations: R2 gross residual disease, EBRT external beam radiation therapy, IOERT intraoperative electron radiation therapy, LC local control, DM distant metastases, OS overall survival, MSKCC Memorial Sloan Kettering Cancer Center, MGH Massachusetts General Hospital,IOHDR intraoperative high dose rate brachytherap
^a20–50 Gy in previously irradiated patients
^b4-year results
^c4-year relapse free survival
^d30.6 Gy in previously irradiated patients
^e5-39.6 Gy in previously irradiated patients

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