Intraoperative radiation therapy for colon and rectal cancers: a clinical review

Radiation Oncology

Table 3 Disease control and survival with IORT for locally recurrent rectal cancer in association with R0 resection. Results of selected series

Study	Years	# Patients	EBRT dose, Gy	IORT dose, Gy	IORT technique	5-year LC	5-year DM	5-year OS
Alektiar, MSKCC [30]	1992–1998	53	50.4^a	10–18	IOHDR	43%	-	36%
Lindel, MGH [31]	1978–1997	25	50.4^b	10–15	IOERT	56%	-	40%
Wiig, Norway [33]	1990–1999	18	46–50	15–20	IOERT	70%	-	60%
Eble, Heidelberg [33] ^c	1991–1995	14	41.4	10–20	IOERT	79%	19%	71%^d
Dresen, Eindhoven [34]	1994–2006	84	50.4^e	10	IOERT	69%	34%	48%
Haddock, Mayo Clinic [19]	1981–2008	236	50.4^f	12.5	IOERT	79%	48%	46%

Abbreviations: R0 pathologically negative margins, EBRT external beam radiation therapy, IORT intraoperative radiation therapy, LC local control, DM distant metastases, OS overall survival, MSKCC Memorial Sloan Kettering Cancer Center, MGH Massachusetts General Hospital, IOHDR Intraoperative high dose rate brachytherapy
^a50.4 in patients with no prior EBRT; no EBRT in patients with prior radiation
^b20–50 Gy in previously irradiated patients
^c4-year results
^d4-year relapse free survival
^e30.6 Gy in previously irradiated patients
^f5–39.6 Gy in previously irradiated patients

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