Table 2 Disease control and survival with IORT for locally advanced rectal cancer. Results of selected series
From: Intraoperative radiation therapy for colon and rectal cancers: a clinical review
Study | # Patients | Years | EBRT dose, Gy | Margins | IORT dose, Gy | 5-year LC | 5-year DM | 5-year OS |
|---|---|---|---|---|---|---|---|---|
Willett, MGH [42] | 20 | 1978–1989 | 50.4 | R0 | 10–20 | 88% | - | 53%a |
Valentini, Rome [43] | 29 | 1991–2006 | 45–55 | R0 | 10–15 | 100% | - | - |
Alberda, Rotterdam [44] | 31 | 1996–2012 | 45–50b | R1 | 10c | 84% | - | - |
Zhang, Shanghai [45] | 71 | 1994–2007 | 45–50.4 | R0-1 | 10–20 | 90% | 54% | 75% |
Sadahiro, Japan [46] | 99 | 1991–2001 | 20 | ns | 15–25 | 98% | 20% | 79% |
Mathis, Mayo Clinic [6] | 106 | 1981–2007 | 50.4 | R0-2 | 7.5–25 | 86%d | 49%d | 49% |
Roeder, Heidelberg [47] | 243 | 1991–2004 | 41.4 | R0-2 | 10–15 | 92% | - | - |
Sole, Madrid [23] | 335 | 1995–2010 | 45–50.4 | R0-1 | 10–15 | 92% | 25%e | 75% |
Kusters, European pooled [24] | 605 | to 2005 | 45–50.4 | R0-2 | 10–12.5 | 88% | 29% | 67% |