Intraoperative radiation therapy (IORT) in soft-tissue sarcoma

Radiation Oncology

Table 1 Results of major IORT series in extremity sarcoma

Author	Year	Type	n	f/u	R0	IORT	EBRT	5y-LC	5y-OS	LP	FC
Petersen [32]	1999	r,sc	91	34	n.r.	10–15	45–50	92^b	76^b	n.r.	n.r.
Edmonson [33]	2001	r,sc	39	70	62	10–20	45	90^a	80	95	n.r.
Azinovic [34]	2003	r,sc	45	93	67	15	45–50	80^a	64^a	88	77
Kretzler [5]	2004	r,sc	28	52	61	12–15	50	84	66	100	59
Oertel [6]	2006	r,sc	128^c	33	49	15	45	83	83	90	86
Llacer [35]	2006	r,sc	79	58	42	20 (LDR)	45–50	90	69	100	n.r.
Alvarez [36]	2008	r,sc	53	66	n.r.	7.5–12.5	n.r.	87	75	83	81
Callister [37]	2008	r,sc	48	20	83	10–15	50	83^b	84^b	n.r.	n.r.
Roeder [29]	2013	p,sc	34	43	88	10–15	40–50	97	79	94	81
Calvo [40]	2014	r,mc	159	67	84	12.5	45	82	72	94	n.r.
Roeder [30]	2015	r,sc	183	64	68	15	45	86	71	95	83
Roeder [39]	2015	r,mc	259	63	71	12	45	86	78	95	81

year year of publication; type type of study; r retrospective; p porspective; sc single-center; mc multi-center; n number of patients; f/u median follow up in months; R0 rate of microscopic complete resections in %; IORT intraoperative radiation therapy dose in Gy (median or range); LDR low dose rate brachytherapy; EBRT external beam radiation therapy dose in Gy (median or range); 5y-LC estimated 5-year-local control rate in %; 5y-OS estimated 5-year-overall survival rate in %; LP limb preservation rate in %; FC rate of excellent/good functional outcome in %; ^a: crude rates, ^b: estimated 3-year rates, ^c: excluding patients with distant metastases at time of surgery

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