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Table 3 Excess lifetime attributable risk (LAR) VMAT vs 3DCRT

From: Estimation of second cancer risk after radiotherapy for rectal cancer: comparison of 3D conformal radiotherapy and volumetric modulated arc therapy using different high dose fractionation schemes

Organa

25 × 1.8 Gy (VMAT > LAR)

5 × 5 Gy (VMAT > LAR)

Median (%)

95 % CI

p-value

Median (%)

95 % CI

p-value

Anus

0.0145

0.0016–0.0406

0.016

0.0088

0.0013–0.0241

0.013

Bladder

0.0934

0.0486–0.1491

<0.001

0.0988

0.0568–0.1572

<0.001

Bones R = 1

0.0066

−0.0223–0.0171

0.458

0.0057

−0.0089–0.0114

0.312

Bones R = 0.5

0.0040

−0.0057–0.0080

0.287

0.0026

−0.0019–0.0046

0.220

Bones R = 0.1

0.0003

−0.0002–0.0006

0.202

0.0001

−0.0001–0.0003

0.182

Colon

0.0768

0.0097–0.2674

0.015

0.0417

0.0051–0.1474

0.012

Sigmoid

0.0054

−0.0077–0.0152

0.367

0.0040

−0.0036–0.0106

0.241

Skin

0.0050

0.0027–0.0073

<0.001

0.0028

0.0014–0.0040

<0.001

Small bowel

0.0064

0.0137–0.0259

<0.001

0.0094

0.0052–0.0147

<0.001

Soft tissue R = 1

0.0195

0.0137–0.0259

<0.001

0.0094

0.0021–0.0042

<0.001

Soft tissue R = 0.5

0.0072

0.0050–0.0097

<0.001

0.0031

0.0050–0.0097

<0.001

Soft tissue R = 0.1

0.0005

0.0003–0.0006

<0.001

0.0002

0.0001–0.0003

<0.001

Prostate

0.0002

−0.0026–0.0043

0.787

0.0001

−0.0024–0.0034

0.893

Uterus

0.0089

0.0055–0.0555

0.063

0.0077

0.0042–0.0546

0.063

  1. VMAT volumetric modulated arc therapy, 3DCRT 3 dimensional conformal radiotherapy, R regeneration rate for soft tissue and bones, with possible sarcoma induction, CI confidence interval
  2. afemale/male data mixed if not otherwise indicated
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Radiation Oncology

ISSN: 1748-717X

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