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Table 2 Excess lifetime attributable risk (LAR) after RT

From: Estimation of second cancer risk after radiotherapy for rectal cancer: comparison of 3D conformal radiotherapy and volumetric modulated arc therapy using different high dose fractionation schemes

Organa

Mean LAR VMAT (%)

Mean LAR 3DCRT (%)

25 × 1.8 Gy

5 × 5 Gy

25 × 1.8 Gy

5 × 5 Gy

Anus

0.3330

0.1973

0.3098

0.1835

Bladder

0.2151

0.2260

0.1067

0.1144

Bones R = 1

0.1734

0.0881

0.1756

0.0864

Bones R = 0.5

0.0591

0.0273

0.0573

0.0257

Bones R = 0.1

0.0031

0.0013

0.0029

0.0013

Colon

1.0225

0.5677

0.8554

0.4754

Sigmoid

0.4732

0.2882

0.4981

0.3020

Skin

0.0519

0.0288

0.0461

0.0256

Small bowel

0.1328

0.1088

0.1240

0.0977

Soft tissue R = 1

0.1007

0.0474

0.0768

0.0357

Soft tissue R = 0.5

0.0344

0.0153

0.0254

0.0115

Soft tissue R = 0.1

0.0024

0.0011

0.0019

0.0008

Prostate

0.0354

0.0242

0.0346

0.0236

Ovaries

0.2756

0.1944

0.2838

0.2053

Uterus

0.1997

0.1383

0.1826

0.1220

All organs male R = 1

2.5380

1.5764

2.2270

1.3443

All organs male R = 0.5

2.3574

1.4835

2.0573

1.2593

All organs male R = 0.1

2.2694

1.4433

1.9795

1.2242

All organs female R = 1

2.9778

1.8849

2.6589

1.6480

All organs female R = 0.5

2.7972

1.7920

2.4892

1.5630

All organs female R = 0.1

2.7093

1.7518

2.4113

1.5279

  1. VMAT volumetric modulated arc therapy, 3DCRT 3 dimensional conformal radiotherapy, R regeneration rate for soft tissue and bones, with possible sarcoma induction
  2. afemale/male data mixed if not otherwise indicated
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Radiation Oncology

ISSN: 1748-717X

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