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Table 3 Optimal rAUC25–50 cut-off value related to acute GI toxicity Grade ≥ 1 determined using a ROC curve (multivariate logistic regression)

From: Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer

  Univariate analysis Multivariate analysis Bootstrapping (170 rep)
Acute GIa toxicity G ≥ 1 / N ORc 95 % CId p-value Acute GI toxicity G ≥ 1 / N OR 95 % CI p-value 95 % CI p-value
  115/178
rAUC25-50 b rectum
 Liu/Youden cutting methods
   < =794 cc.Gy 29/59 1   0.002 28 / 58 1   0.020   0.019
   > 794 cc.Gy 88/121 2.76 [1.44;5.28]   87 / 120 2.51 [1.16;5.46]   [1.16;5.42]  
Adjustment variables
 Age
   < 70 years 57/82 1   0.247 57 / 82 1   0.233   0.226
   > = 70 years 60/ 98 0.69 [0.37;1.29]   58 / 96 0.67 [0.35;1.29]   [0.35;1.28]  
TURPe
 No 95/143 1   0.305 95 / 143 1   0.423   0.459
 Yes 20/35 0.67 [0.32;1.43]   20 / 35 0.72 [0.33;1.59]   [0.31;1.7]  
HTf
 No 65/104 1   0.411 64 / 103 1   0.757   0.755
 Yes 52/76 1.3 [0.7;2.43]   51 / 75 1.11 [0.57;2.16]   [0.57;2.15]  
Rectum Volume (cc) per unit   1   0.041   1   0.558   0.570
  1.01 [1;1.02]    1 [0.99;1.01]   [0.99;1.01]  
  1. agastrointestinal; bArea Under the Curve of rectal DHV between 25 and 50Gy, codds ratio; d95 % confidence interval;e transurethral resection of the prostate; fhormonotherapy