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Table 3 Optimal rAUC25–50 cut-off value related to acute GI toxicity Grade ≥ 1 determined using a ROC curve (multivariate logistic regression)

From: Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer

 

Univariate analysis

Multivariate analysis

Bootstrapping (170 rep)

Acute GIa toxicity G ≥ 1 / N

ORc

95 % CId

p-value

Acute GI toxicity G ≥ 1 / N

OR

95 % CI

p-value

95 % CI

p-value

 

115/178

rAUC25-50 b rectum

 Liu/Youden cutting methods

   < =794 cc.Gy

29/59

1

 

0.002

28 / 58

1

 

0.020

 

0.019

   > 794 cc.Gy

88/121

2.76

[1.44;5.28]

 

87 / 120

2.51

[1.16;5.46]

 

[1.16;5.42]

 

Adjustment variables

 Age

   < 70 years

57/82

1

 

0.247

57 / 82

1

 

0.233

 

0.226

   > = 70 years

60/ 98

0.69

[0.37;1.29]

 

58 / 96

0.67

[0.35;1.29]

 

[0.35;1.28]

 

TURPe

 No

95/143

1

 

0.305

95 / 143

1

 

0.423

 

0.459

 Yes

20/35

0.67

[0.32;1.43]

 

20 / 35

0.72

[0.33;1.59]

 

[0.31;1.7]

 

HTf

 No

65/104

1

 

0.411

64 / 103

1

 

0.757

 

0.755

 Yes

52/76

1.3

[0.7;2.43]

 

51 / 75

1.11

[0.57;2.16]

 

[0.57;2.15]

 

Rectum Volume (cc) per unit

 

1

 

0.041

 

1

 

0.558

 

0.570

 

1.01

[1;1.02]

  

1

[0.99;1.01]

 

[0.99;1.01]

 
  1. agastrointestinal; bArea Under the Curve of rectal DHV between 25 and 50Gy, codds ratio; d95 % confidence interval;e transurethral resection of the prostate; fhormonotherapy
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Radiation Oncology

ISSN: 1748-717X

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