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Table 2 Evaluation of relationship between DVSE and acute gastrointestinal toxicity using univariate logistic regression analysis

From: Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer

Median [range] All patients Patients with acute toxicities Gb = 0 Patients with acute toxicities G ≥ 1 p-value
n = 180 n = 63 n = 117  
Rectum volumes expressed in %  
 V25a 68 [27;100] 69.6 [27;100] 67.7 [31.6;100] 0.799
 V30 60.9 [24.2;100] 61.6 [24.2;100] 60.7 [25.5;100] 0.860
 V35 51.9 [21;100] 51.7 [21.8;99.6] 52.1 [21;100] 0.726
 V40 44 [17.6;96.7] 44.3 [19.7;85.3] 43.9 [17.6;96.7] 0.638
 V45 35.2 [13.1;82.2] 37.1 [15.5;62.8] 34.8 [13.1;82.2] 0.704
 V50 27.8 [8;74.6] 28.3 [9.3;52.9] 27.7 [8;74.6] 0.766
 V55 22.4 [5.4;51.2] 23 [5.4;43.6] 22.3 [6.1;51.2] 0.875
 V60 17.2 [2.7;40.8] 17.6 [2.7;35.1] 17 [3.4;40.8] 0.918
 V65 11.8 [1;29.5] 12.6 [1;29.5] 11.5 [1.2;26.5] 0.582
 V70 7.3 [0;23.1] 7.8 [0;23.1] 6.7 [0;19.8] 0.217
 V75 0.9 [0;11.4] 1.5 [0;11.4] 0.7 [0;9.1] 0.124
Rectum volumes expressed in cc  
 V25 53.5 [20.1;223] 48.8 [20.1;114] 57 [20.6;223] 0.039
 V30 47.5 [19.5;180.2] 42.8 [19.5;99.8] 50.9 [19.8;180.2] 0.045
 V35 41.7 [16.7;150] 37.8 [16.7;86] 42.6 [17.4;150] 0.035
 V40 36.1 [11;120.8] 31.9 [11;79] 37.4 [13.9;120.8] 0.025
 V45 29.8 [8;101.9] 25.8 [8;69.1] 31.6 [10.2;101.9] 0.018
 V50 24.1 [5.9;77] 21.1 [5.9;58.1] 25 [7.6;77] 0.035
 V55 19 [4.4;56.4] 17.9 [4.4;47.8] 19.7 [5.8;56.4] 0.069
 V60 14.6 [2.4;43.6] 13.1 [2.4;36.3] 15.2 [3.1;43.6] 0.17
 V65 10.2 [0.9;36.8] 9.9 [0.9;28.7] 11 [1.3;36.8] 0.387
 V70 5.7 [0;29.5] 5.8 [0;20.2] 5.7 [0;29.5] 0.853
 V75 0.8 [0;16.2] 0.9 [0;8] 0.6 [0;16.2] 0.232
 rAUC25–50 (cc. Gy) c 972.5 [388.5;3305.3] 835.7 [394.3;2008.8] 1002.4 [388.5;3305.3] 0.028
  1. a Vx = volume of rectum receiving xGy; b Grade using CTC-AE V3.0 validated scale; c Area Under the Curve of rectal DHV between 25 and 50Gy