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Table 1 Summary of which parameters (odds ratios, VX and DX%) correlate with toxicity

From: Prostate external beam radiotherapy combined with high-dose-rate brachytherapy: dose-volume parameters from deformably-registered plans correlate with late gastrointestinal complications

Toxicity type

Distribution-adding

Parameter-adding

Odds ratioa

VX b

DX% c

DX% c

Rectal bleeding

01–05 Gy

48–80 Gy

48–80 Gy

01–25 %

68–78 %

01–25 %

62–78 %

Stool frequency

49–55 Gy

49–57 Gy

07–18 %

02–24 %

58–73 %

Diarrhoea

51 Gy

50–59 Gy

08–13 %

None

Completeness of evacuation

None

None

None

None

Anorectal pain

44–48 Gy

45–48 Gy

None

None

Urgency/tenesmus

25–26 Gy

40–63 Gy

25–27 Gy

43–64 Gy

05–38 %

56–74 %

None

Proctitis

None

None

None

59–70 %

  1. Abbreviations: V X percentage of the rectal volume receiving at least X EQD2 Gy after applying an α/β = 3 Gy, D X% minimum EQD2 Gy dose to the most irradiated X percentage of rectal volume after applying an α/β = 3 Gy, EQD2 Gy equivalent dose in 2-Gy fractions using α/β = 3 Gy, α/β alpha-beta ratio
  2. aDoses at which odds ratios were significantly different from a value of one
  3. bDoses at which the median VX for toxicity and no toxicity groups were significantly different
  4. cVolumes at which the median DX% for toxicity and no toxicity groups were significantly different