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Table 1 Plan comparison between IMRT, PBT and PAT. (average of nine patients)

From: A treatment planning study of proton arc therapy for para-aortic lymph node tumors: dosimetric evaluation of conventional proton therapy, proton arc therapy, and intensity modulated radiotherapy

 

IMRT

PBT

PAT

P*

PTV

 Coverage (%)

98.5 ± 0.02

99.0 ± 0.01

99.6 ± 0.01

IMRT vs. PAT (1.000), PBT vs. PAT (0.145)

 D2% (Gy)

63.2 ± 0.04

62.8 ± 0.04

62.4 ± 0.02

IMRT vs. PAT (0.002), PBT vs. PAT (1.000)

 D98% (Gy)

59.1 ± 0.05

59.4 ± 0.01

59.8 ± 0.02

IMRT vs. PAT (1.000), PBT vs. PAT (1.000)

 Dmean (Gy)

61.9 ± 0.02

61.4 ± 0.03

61.6 ± 0.03

IMRT vs. PAT (1.000), PBT vs. PAT (0.371)

 Conformity index (CI)

1.47 ± 0.03

1.23 ± 0.03

1.19 ± 0.02

IMRT vs. PAT (<0.001), PBT vs. PAT (1.000)

 Homogeneity index (HI)

6.83 ± 0.02

5.67 ± 0.01

4.33 ± 0.02

IMRT vs. PAT (0.003), PBT vs. PAT (<0.001)

Stomach

 V30% (%)

41.5 ± 4.1

26.4 ± 14.3

23.7 ± 8.1

IMRT vs. PAT (<0.001), PBT vs. PAT (<0.001)

 V60% (%)

12.5 ± 1.5

14.8 ± 5.4

11.3 ± 5.6

IMRT vs. PAT (<0.001), PBT vs. PAT (0.018)

 V90% (%)

0.09 ± 0.4

4.25 ± 2.1

3.15 ± 0.9

IMRT vs. PAT (<0.001), PBT vs. PAT (0.002)

 Dmean (Gy)

16.2 ± 1.6

9.84 ± 3.2

10.1 ± 8.4

IMRT vs. PAT (<0.001), PBT vs. PAT (0.518)

Small bowel

 V30% (%)

26.2 ± 7.5

17.5 ± 10.2

12.7 ± 4.2

IMRT vs. PAT (<0.001), PBT vs. PAT (<0.001)

 V60% (%)

2.50 ± 4.2

0.63 ± 4.3

0.73 ± 1.1

IMRT vs. PAT (<0.001), PBT vs. PAT (0.327)

 V90% (%)

0.20 ± 1.3

0.11 ± 1.2

0.02 ± 0.4

IMRT vs. PAT (0.402), PBT vs. PAT (0.039)

 Dmean (Gy)

18.7 ± 1.1

14.9 ± 2.9

15.8 ± 1.9

IMRT vs. PAT (0.365), PBT vs. PAT (0.521)

Kidney

 V30% (%)

12.0 ± 6.3

0.96 ± 2.4

1.10 ± 3.5

IMRT vs. PAT (<0.001), PBT vs. PAT (0.960)

 V60% (%)

1.46 ± 3.9

0

0

IMRT vs. PAT (0.053), PBT vs. PAT (0.321)

 V90% (%)

0.36 ± 1.4

0

0

IMRT vs. PAT (1.000), PBT vs. PAT (1.000)

 Dmean (Gy)

6.61 ± 2.9

1.10 ± 3.3

2.41 ± 2.6

IMRT vs. PAT (1.000), PBT vs. PAT (0.412)

Liver

 V30% (%)

10.5 ± 0.9

8.91 ± 6.7

8.02 ± 4.5

IMRT vs. PAT (<0.001), PBT vs. PAT (1.000)

 V60% (%)

0.16 ± 0.7

2.16 ± 2.6

1.62 ± 1.7

IMRT vs. PAT (<0.001), PBT vs. PAT (0.852)

 V90% (%)

0.02 ± 0.4

0.02 ± 1.3

0.05 ± 1.5

IMRT vs. PAT (0.532), PBT vs. PAT (1.000)

 Dmean (Gy)

10.6 ± 0.4

7.38 ± 1.9

7.88 ± 1.2

IMRT vs. PAT (1.000), PBT vs. PAT (1.000)

Spinal cord

 V30 % (%)

29.7 ± 7.7

21.5 ± 9.4

0

IMRT vs. PAT (<0.001), PBT vs. PAT (<0.001)

 V60 % (%)

8.68 ± 8.2

0

0

IMRT vs. PAT (<0.001), PBT vs. PAT (1.000)

 V90 % (%)

0

0

0

IMRT vs. PAT (1.000), PBT vs. PAT (1.000)

 Dmean (Gy)

15.0 ± 4.2

6.21 ± 6.5

0.92 ± 0.7

IMRT vs. PAT (<0.001), PBT vs. PAT (1.000)

  1. Abbreviations D x%dose received by the x% of the volume, V x% volume receiving at least x% of the prescribed dose. Average parameters ± standard deviation (k = 1) are displayed
  2. *p values of ≤0.05 considered significant; p values of <0.001 were truncated and noted as p < 0.001