Apparent diffusion coefficient histogram shape analysis for monitoring early response in patients with advanced cervical cancers undergoing concurrent chemo-radiotherapy

Table 6 ADC histogram shape related parameters of healthy cervical tissue during CCRT in patients with cervical cancers

Parameter	Time point 1	Time point 2	Time point 3	Time point 4
Skewness	0.03 ± 0.12	0.01 ± 0.15	0.04 ± 0.11	0.02 ± 0.13
Kurtosis	0.09 ± 0.03	0.07 ± 0.03	0.07 ± 0.04	0.07 ± 0.02
First-order entropy	3.75 ± 0.38	3.52 ± 0.36	3.48 ± 0.16	3.73 ± 0.27
Entropy(H)_mean	6.16 ± 0.56	5.71 ± 0.60	5.64 ± 0.26	5.96 ± 0.67
s-sD_av (×10⁻⁶ mm²/s)	1114.40 ± 602.64	1190.40 ± 427.14	1200.70 ± 451.39	1187.00 ± 484.02
Width (×10⁻⁶ mm²/s)	769.90 ± 227.77	746.10 ± 281.49	782.80 ± 316.62	739.10 ± 154.28
Standard deviation	283.47 ± 81.58	286.46 ± 89.72	292.76 ± 119.15	286.21 ± 56.61

Note: ADC, apparent diffusion coefficient; CCRT, concurrent chemo-radiotherapy. Data are presented as mean ± standard deviation. Time point 1: before CCRT; Time point 2: at the end of 2nd week of CCRT; Time point 3: at the end of 4th week of CCRT; Time point 4: immediately after CCRT completion

ISSN: 1748-717X