Apparent diffusion coefficient histogram shape analysis for monitoring early response in patients with advanced cervical cancers undergoing concurrent chemo-radiotherapy

Table 3 Second-order entropies during the CCRT course in patients with advanced cervical cancers

Second-order entropy	Time point 1	Time point 2	Time point 3	Time point 4
entropy(H)₁	10.24 ± 2.53	9.15 ± 2.89	5.06 ± 3.49^§	3.12 ± 2.72^#
entropy(H)₂	10.27 ± 2.53	9.18 ± 2.89	5.10 ± 3.53^§	3.22 ± 2.74^#
entropy(H)₃	10.25 ± 2.53	9.14 ± 2.96	4.96 ± 3.63^§	3.08 ± 2.78^#
entropy(H)₄	10.27 ± 2.49	9.18 ± 2.85	5.16 ± 3.41^§	3.28 ± 2.59^#
entropy(H)₅	10.28 ± 2.50	9.21 ± 2.87	5.20 ± 3.42^§	3.38 ± 2.62^#
entropy(H)₆	10.25 ± 2.52	9.16 ± 2.94	5.09 ± 3.47^§	3.25 ± 2.66^#
entropy(H)₇	10.24 ± 2.50	9.13 ± 2.87	4.96 ± 3.43^§	3.09 ± 2.55^#
entropy(H)₈	10.25 ± 2.51	9.15 ± 2.90	5.09 ± 3.34^§	3.32 ± 2.52^#
entropy(H)₉	10.22 ± 2.53	9.11 ± 2.98	4.88 ± 3.55^§	3.19 ± 2.57^#
entropy(H)₁₀	10.45 ± 2.42	9.98 ± 2.05	6.66 ± 2.66^§	5.07 ± 2.28^#
entropy(H)₁₁	10.18 ± 2.61	9.67 ± 2.35	6.86 ± 2.53^§	5.40 ± 2.07^#
entropy(H)₁₂	10.45 ± 2.43	9.98 ± 2.06	6.65 ± 2.71^§	5.19 ± 2.19^#

Note: ADC apparent diffusion coefficient, CCRT concurrent chemo-radiotherapy
Data are presented as mean ± standard deviation
^§ P < 0.05: data show statistical difference between time point 3 and 2; ^# P < 0.05: data show statistical difference between time point 4 and 3
Time point 1: before CCRT; Time point 2: at the end of 2nd week of CCRT; Time point 3: at the end of 4th week of CCRT; Time point 4: immediately after CCRT completion

ISSN: 1748-717X