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Table 2 ADC histogram shape related parameters during the CCRT course in patients with advanced cervical cancers

From: Apparent diffusion coefficient histogram shape analysis for monitoring early response in patients with advanced cervical cancers undergoing concurrent chemo-radiotherapy

Parameter

Time point 1

Time point 2

Time point 3

Time point 4

Skewness

1.16 ± 0.53

0.66 ± 0.57*

0.17 ± 0.30§

0.04 ± 0.16

Kurtosis

2.34 ± 1.56

1.21 ± 1.16*

0.30 ± 0.51§

0.11 ± 0.10

First-order entropy

6.22 ± 0.45

5.74 ± 0.89

4.17 ± 1.40§

3.38 ± 1.19#

Entropy(H)mean

10.22 ± 2.50

9.69 ± 2.36

6.93 ± 2.43§

5.55 ± 1.88#

s-sDav (×10−6 mm2/s)

555.43 ± 453.93

623.00 ± 419.74

801.11 ± 591.85

1083.86 ± 560.68#

Width (×10−6 mm2/s)

705.43 ± 276.28

648.39 ± 249.47

714.68 ± 353.48

649.79 ± 523.89

Standard deviation

294.68 ± 94.37

271.56 ± 91.24

277.81 ± 134.01

270.68 ± 132.35

Longest diameter (cm)

4.49 ± 1.09

3.19 ± 1.13*

1.55 ± 1.40§

0.30 ± 0.69#

Volume (cm3)

30.95 ± 23.97

15.74 ± 16.46*

3.11 ± 7.65§

0.34 ± 0.79

  1. Note: ADC apparent diffusion coefficient, CCRT concurrent chemo-radiotherapy
  2. Data are presented as mean ± standard deviation
  3. * P < 0.05: data show statistical difference between time point 2 and 1; § P < 0.05: data show statistical difference between time point 3 and 2; # P < 0.05: data show statistical difference between time point 4 and 3
  4. Time point 1: before CCRT; Time point 2: at the end of 2nd week of CCRT; Time point 3: at the end of 4th week of CCRT; Time point 4: immediately after CCRT completion