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Table 1 Patient characteristics

From: Suspected recurrence of brain metastases after focused high dose radiotherapy: can [18F]FET- PET overcome diagnostic uncertainties?

Lesion number

Location

Histology

Previous RT

TBR max

TBR mean

TAC

TTP

Months between RT and PET

Final diagnosis

Diagnostic determinant

Follow up (months)

1

R parietal

NSCLC

SRS

1.5

1.4

n.a.

n.a.

1.9

Radiation induced lesion

Follow up

9.4

2

L insular

Malignant melanoma

SBT

3.4

2.3

Decreasing

12.5

2.1

Tumor

Follow up

14.8

3

L insular

Malignant melanoma

SRS

3.4

2.3

Increasing

35

2.2

Tumor

Histology

4.2

4

L parietooccipital

NSCLC

SBT

2.1

1.9

Decreasing

25

2.4

Tumor

Histology

29.9

5

L occipital

NSCLC

SBT

2.8

2.1

Increasing

35

2.5

Radiation induced lesion

Follow up

6.7

6

L frontal

Malignant melanoma

SBT

4.1

2.5

Increasing

35

2.6

Tumor

Follow up

4.6

7

L parietal

CUP

SRS

1.8

1.8

Increasing

35

3

Radiation induced lesion

Follow up

4.9

8

L pontine

Breast cancer

SRS

1.5

1.3

n.a.

n.a.

4.6

Radiation induced lesion

Follow up

30.9

9

R temporal

Malignant melanoma

SRS

2.1

1.9

Increasing

17.5

4.7

Radiation induced lesion

Follow up

16

10

L frontal

Malignant melanoma

SRS

2.0

1.9

Decreasing

17.5

4.7

Tumor

Histology

16

11

L cerebellar

Breast cancer

SRS

1.7

1.2

Increasing

35

4.7

Radiation induced lesion

Follow up

30.9

12

R parietal

Malignant melanoma

SRS

1.4

1.0

n.a.

n.a.

4.8

Radiation induced lesion

Follow up

6.8

13

R parietal

NSCLC

SRS

1.5

1.4

n.a.

n.a.

5.3

Tumor

Histology

9.4

14

L insular

Malignant melanoma

SBT

3.2

2.3

Decreasing

17.5

5.4

Radiation induced lesion

Follow up

14.8

15

R temporal

NSCLC

SRS

1.5

1.3

n.a.

n.a.

6

Radiation induced lesion

Follow up

13.6

16

L occipital

NSCLC

SRS

2.8

2.1

Decreasing

12.5

6

Tumor

Histology

13.6

17

L temporal

Malignant melanoma

SRS

2.9

2.1

Increasing

35

6

Radiation induced lesion

Follow up

33.8

18**

R frontal

Malignant melanoma

SRS

1.4

1.3

Increasing

35

8

Radiation induced lesion

Follow up

42.5

19

R cerebellar

Gastrointestinal cancer

SRS

2.3

2.0

Decreasing

12.5

8.5

Tumor

Histology

18

20

L frontal

NSCLC

SRS

1.9

1.8

Increasing

35

8.6

Radiation induced lesion

Histology

35.1

21

R frontal

NSCLC

SRS

1.6

1.4

Increasing

35

8.7

Radiation induced lesion

Histology

43.1

22

L frontal

NSCLC

SRS

1.2

1.0

n.a.

n.a.

8.7

Radiation induced lesion

Follow up

43.1

23

L frontal

Malignant melanoma

SRS

2.4

2.0

Decreasing

25

9.1

Tumor

Histology

22.2

24

R frontal

Gastrointestinal cancer

SRS

2.0

1.9

Increasing

25

9.3

Radiation induced lesion

Histology

17.1

25

R frontal

NSCLC

SRS

2.0

1.9

Decreasing

25

9.3

Radiation induced lesion

Histology

23.8

26

R temporal

NSCLC

SRS

1.5

1.1

n.a.

n.a.

9.4

Radiation induced lesion

Follow up

13.6

27

L insular

Malignant melanoma

SBT

3.5

2.4

Decreasing

7.5

10.5

Radiation induced lesion

Follow up

14.8

28

L parietal

Malignant melanoma

SBT

2.5

2.1

Decreasing

12.5

12.3

Tumor

Histology

14.5

29

R temporal

Malignant melanoma

SRS

1.5

1.2

n.a.

n.a.

14

Radiation induced lesion

Follow up

16

30*

L frontal

Malignant melanoma

SRS

3.5

2.3

Decreasing

7.5

14

Tumor

Histology

16

31

L insular

Malignant melanoma

SBT

3.5

2.4

Decreasing

12.5

14.7

Radiation induced lesion

Follow up

14.8

32

R occipital

Breast cancer

SRS

1.8

1.8

Increasing

35

15

Radiation induced lesion

Follow up

79.2

33

R frontal

Breast cancer

SRS

2.0

1.9

Increasing

35

15

Radiation induced lesion

Follow up

79.2

34

L cerebellar

Breast cancer

SRS

1.8

1.7

Increasing

35

15

Radiation induced lesion

Follow up

79.2

35

L occipital

NSCLC

SRS

3.0

2.1

Decreasing

4

15.8

Tumor

Histology

25.1

36

L frontal

Malignant melanoma

SRS

2.1

1.9

Increasing

35

18.2

Radiation induced lesion

Follow up

24.1

37

R frontal

NSCLC

SRS

3.0

2.2

Decreasing

12.5

18.6

Tumor

Follow up

23.8

38

R frontal

Malignant melanoma

SRS

3.5

2.2

Increasing

25

19.8

Tumor

Follow up

42.5

39

R frontal

Malignant melanoma

SRS

2.2

2.0

Decreasing

4

19.8

Tumor

Follow up

42.5

40

L cerebellar

Breast cancer

SRS

3.8

2.7

Increasing

35

19.9

Tumor

Histology

30.9

41

L pontine

Breast cancer

SRS

4.3

2.8

Decreasing

25

19.9

Tumor

Histology

30,9

42

L frontal

Malignant melanoma

SRS

2.0

1.9

Decreasing

17.5

20.3

Radiation induced lesion

Follow up

24.1

43

L frontal

Malignant melanoma

SRS

2.4

2.0

Decreasing

25

20.8

Tumor

Histology

22.2

44

R frontal

NSCLC

SRS

3.9

2.6

Decreasing

12.5

22.6

Tumor

Follow up

23.8

45

R frontal

Breast cancer

SRS

1.5

1.4

Decreasing

25

22.9

Radiation induced lesion

Follow up

33

46

L cerebellar

Breast cancer

SRS

2.4

2.0

Decreasing

17.5

22.9

Tumor

Histology

33

47

R cerebellar

NSCLC

SRS

2.6

2.0

Decreasing

17.5

23.5

Radiation induced lesion

Histology

33.6

48

R frontal

Malignant melanoma

SRS

1.4

1.3

Decreasing

4

28.4

Radiation induced lesion

Follow up

42.5

49

L parietal

NSCLC

SRS

1.7

1.5

Increasing

35

42.2

Radiation induced lesion

Follow up

51.5

50

R cerebellar

Renal cell carcinoma

SRS

2.9

2.1

Decreasing

17.5

90.3

Tumor

Histology

99.1

  1. (*Fig. 1)
  2. (**Fig. 2)