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Table 4 Multivariate analysis

From: Mucosal melanoma of the head and neck: a population-based study from Slovenia, 1985-2013

Prognostic factora LC LRC DMFS OS
HR (95 % CI) p-value HR (95 % CI) p-value HR (95 % CI) p-value HR (95 % CI) p-value
Age (years)
 <65 NI   NI   1.0   1.0  
 >65      1.2 (0.40–3.4) 0.793 0.89 (0.31–2.6) 0.836
Performance status (WHO)
 0 1.0 0.523 1.0 0.473 NI   1.0 0.022
 1 0.73 (0.24–2.2) 0.576 0.61 (0.23–1.6) 0.315    1.2 (0.52–2.9) 0.640
 2+3+4 1.9 (0.31–12) 0.483 1.4 (0.25–7.6) 0.722    7.7 (1.7–34) 0.008
Site
 SN 2.1 (0.52–8.7) 0.298 2.1 (0.64–7.4) 0.216 NI   NI  
 OC-OP 1.0   1.0      
Pigmented lesion
 Yes NI   NI   1.0   NI  
 No      1.2 (0.40–3.4) 0.779   
Treatment modality
 Surgery 2.2 (0.42–12) 0.355 4.7 (0.98–22) 0.054 NI   1.0 (0.46–2.2) 0.979
 RT 11 (2.1–63) 0.005 16 (3.0–80) 0.001    2.0 (0.73–5.5) 0.175
 surgery+PORT 1.0 0.005 1.0 0.002    1.0 0.303
Systemic therapy
 Yes NI   NI   1.0   1.0  
 No      2.6 (0.62–11) 0.193 3.1 (0.92–10) 0.068
  1. aFactors with no statistical significance in univariate analysis were included if deemed clinically relevant
  2. NI not included in multivariate analysis, LC Local control, LRC Locoregional control, DMFS Distant metastasis-free survival, OS Overall survival, WHO World Health Organization, SN Sinonasal, OC-OP Oral cavity/oropharynx, RT Radiotherapy, PORT Postoperative radiotherapy