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Table 1 Objective function parameters for all volumes v

From: Worst case optimization for interfractional motion mitigation in carbon ion therapy of pancreatic cancer

v

d O [Gy(RBE)]

d U [Gy(RBE)]

p v

GTV

54

54

Individual

Spinal Cord

10

–

200

Kidneys

5

–

250

Stomach

15

–

15

Intestine

15

–

15

Liver

15

–

15

Normal Tissue

15

–

5

  1. d O/U hresholds for over- and under-dose, respectively. Note that the dose values have to be converted into thresholds in over- and under-effect according to the LQM for effect-based optimization. For the target volumes, the penalties p v were adjusted individually for all four treatment planning strategies but kept the same for OARs