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Table 2 Matched pair comparison of clinical characteristics between the radiosensitive group and the radioresistant group. Multivariate analysis of Cox proportional hazards model for 5-year LRRFS, OS, PFS, and DMFS (n = 733)

From: Prognostic value of phosphorylated Raf kinase inhibitory protein at serine 153 and its predictive effect on the clinical response to radiotherapy in nasopharyngeal carcinoma

Endpoints Prognostic factors HR 95.0 % CI p value
LRRFS p-Ser153 RKIP expression(positive versus negative) 0.133 0.034-0.530 0.004
TNM classification(I + II versus III + IVA+B) 0.310 0.092-1.047 0.059
N classification (N0+1 versus N2+3) 0.276 0.112-0.677 0.005
T classification (T3+4 versus T1+2) 3.594 1.199-10.779 0.022
Sex (female versus male) 0.144 0.023-0.878 0.056
Age (<46 year versus ≥46 year) 1.075 0.992-1.164 0.077
Absolute irradiation dose to neck (Gy) 0.347 0.097-0.910 0.066
Absolute irradiation dose to primary nasopharyngeal site(Gy) 0.211 0.079-0.563 0.062
OS p-Ser153 RKIP expression(positive versus negative) 0.226 0.118-0.432 <0.01
N classification(N0+1 versus N2+3) 0.196 0.055-0.441 0.085
T classification(T3+4 versus T1+2) 2.525 1.083-5.888 0.032
Sex (female versus male) 1.132 1.003-1.362 0.191
Age(<46 versus ≥ 46) 1.032 1.003-1.062 0.271
TNM classification (I + II versus III + IVA+B) 0.310 0.092-1.047 0.059
DMFS p-Ser153 RKIP expression(positive versus negative) 0.093 0.025-0.346 <0.01
N classification(N0+1 versus N2+3) 0.122 0.048-0.425 0.010
T classification (T3+4 versus T1+2) 8.656 1.037-72.232 0.046
Sex (female versus male) 1.032 1.002-1.326 0.121
Age(<46 versus ≥ 46) 1.012 1.013-1.072 0.371
TNM classification (I + II versus III + IVA+B) 0.310 0.092-1.047 0.049
PFS p-Ser153 RKIP expression(positive versus negative) 0.249 0.125-0.493 <0.01
  N classification(N0+1 versus N2+3) 0.226 0.118-0.432 <0.01
  Sex (female versus male) 2.886 0.987-8.439 0.053
  T classification (T3+4 versus T1+2) 3.525 1.083-6.27 0.032
  Age(<46 versus ≥ 46) 1.032 1.003-1.262 0.318
  Absolute irradiation dose to neck (Gy) 0.747 0.497-1.100 0.066
  Absolute irradiation dose to primary nasopharyngeal site(Gy) 0.411 0.079-0.763 0.062
  1. Abbreviations: p-Ser153 RKIP RKIP in phosphorylated form at residue serine153, RKIP Raf kinase inhibitory protein, HR hazard ratio, CI confidence interval, PFS progression-free survival, OS overall survival, DMFS distant metastasis-free survival, LRRFS locoregional relapse-free survival
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Radiation Oncology

ISSN: 1748-717X

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