Fig. 4
From: A critical review of recent developments in radiotherapy for non-small cell lung cancer
Reprinted with permission. Theresa L. Whiteside et al. Clin Cancer Res 2016;22:1845–1855. Schematic representation of immune-mediated abscopal effects. The systemic proinflamatory effects of irradiating a tumor mass results in it being ‘hot’, and acting as an ‘in situ tumor vaccine’ against distant non-irradiated tumors. Such a local response could be enhanced by administering immunostimulatory antibodies in order to attain an enhanced systemic effect, thereby exploiting the immune effects of radiotherapy. CTL, cytotoxic T cell; RT, radiotherapy