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Table 2 Prognostic factors related with overall survival (OS), locoregional relapse-free survival (LRFS), and disease-free survival (DFS)

From: Adjuvant chemoradiotherapy instead of revision radical resection after local excision for high-risk early rectal cancer

 

OS

LRFS

DFS

Univariate

Multivariate

Univariate

Multivariate

Univariate

Multivariate

(No. of patients)

5-year rate (%)

p-value

5-year rate (%)

p-value

5-year rate (%)

p-value

Sex

 

n-s

 

n-s

 

n-s

 Male (57)

94.4

 

92.6

 

90.9

 

 Female (26)

95.8

 

87.6

 

87.6

 

Age

 

n-s

 

n-s

 

n-s

  < 70 (58)

98.2a

 

94.8

 

93.1

 

  ≥ 70 (25)

86.4

 

81.0

 

81.0

 

Location from anal verge

 

n-s

 

n-s

 

n-s

  < 5 cm (33)

96.7

 

93.6

 

90.7

 

  ≥ 5 cm (50)

93.7

 

89.4

 

89.4

 

CEA level

 

n-s

 

n-s

 

n-s

  < 3 ng/ml (49)

100

 

95.6

 

93.6

 

  ≥ 3 ng/ml (34)b

87.0

 

84.0

 

84.3

 

Tumor size

 

n-s

 

n-s

 

n-s

  < 3 cm (62)

94.9

 

89.7

 

88.1

 

  ≥ 3 cm (21)

94.7

 

94.7

 

94.7

 

T-stage

 

n-s

 

n-s

 

0.027 (HR: 4.8, 95 % CI: 1.2–19.1)

 1 (68)

95.2

 

93.7

 

93.8a

 

 2 (15)

93.3

 

80.0

 

73.3

 

Resection margin

 

n-s

 

n-s

 

n-s

  > 3 mm (3)

100

 

100

 

100

 

  ≤ 3 mm (22)

95.5

 

86.4

 

81.8

 

 Unknown (58)

94.3

 

92.1

 

92.1

 

LVI

 

n-s

 

n-s

 

n-s

 No (41)

92.1

 

87.1

 

84.9

 

 Yes (13)

92.3

 

83.9

 

83.9

 

 Unknown (29)

100

 

100

 

100

 

Local excision

 

n-s

 

n-s

 

n-s

 EMR or ESD (26)

92.0

 

88.1

 

88.1

 

 TAE (57)

96.2

 

92.2

 

90.5

 

Radiation dose

 

n-s

 

n-s

 

n-s

  > 50.4 Gy (8)

100

 

100

 

100

 

  ≤ 50.4 Gy (75)

94.3

 

90.0

 

88.7

 

Adjuvant chemotherapy

 

n-s

 

n-s

 

n-s

 Yes (14)

100

 

92.9

 

92.9

 

 No (69)

93.9

 

90.7

 

89.3

 
  1. N-S not significant, LVI lymphovascular invasion, EMR endoscopic mucosal resection, ESD endoscopic submucosal dissection, TAE transanal excision, HR hazard ratio, CI confidence interval, astatistically significant in univariate analysis, b Nine patients of unknown CEA level were included in this subgroup