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Table 2 Ipsilateral neck lymph nodes metastasis in case and control groups

From: High-risk factors of parotid lymph node metastasis in nasopharyngeal carcinoma: a case-control study

Variables

Total No. (%)

Cases(22 sides)

Controls(44 sides)a

p value*

RPNb

 Involvement

53 (80.3)

20

33

0.229

 SLDc

1.8 (0-5.5)

2.4(0-5.5)

1.5(0-4.7)

0.106

 ENSd

43 (65.2)

17

26

0.144

 Necrosis

20 (30.3)

6

14

0.705

Level II

 Involvement

66 (100)

22

44

-

 SLDc

4.5 (1.0-14.7)

6.0(1.5-14.7)

3.6(1.0-9.0)

0.003*

 SLD ≥ 5.0 cm

28 (42.4)

16

12

<0.001*

 ENSd

59 (89.4)

21

38

0.409

 Necrosis

44 (66.7)

19

25

0.016*

Level III

 Involvement

45 (68.2)

16

29

0.575

 SLDc

0.9 (0-7.2)

1.0(0-7.2)

0.8(0-3.8)

0.211

 ENSd

33 (50.0)

10

23

0.602

 Necrosis

14 (21.2)

4

10

0.915

Level IV

 Involvement

21 (31.8)

10

11

0.093

 SLDc

0.0 (0-6.9)

0.0(0-6.9)

0.0(0-2.0)

0.179

 ENSd

15 (22.7)

7

8

0.213

 Necrosis

4 (6.1)

2

2

0.596

Level Va/b

 Involvement

19 (28.8)

10

9

0.034*

 SLDc

0.0 (0-9.3)

0.0(0-9.3)

0.0(0-2.2)

0.299

 ENSd

6 (9.1)

4

2

0.167

 Necrosis

4 (6.1)

3

1

0.104

Rare-neck area involvemente

 

18 (27.3)

12

6

<0.001*

No. of involved levelsf

 Median

2 .0(1-5)

3.5(1-5)

2.0(1-5)

0.045*

  ≥ 4 levels

17 (25.8)

11

6

0.001*

  1. aControl group: The ipsilateral neck with primary tumor center or the side with heavier neck disease in the N2-3 NPC patients without PLNM
  2. bRPN: Retropharyngeal lymph node
  3. cSLD: Sum of the largest diameter for multiple lymph nodes in different neck levels. Median and range were listed in table
  4. dENS: Extra-nodal neoplastic spread
  5. eRare neck areas including level Ia/b, level Vc, and level VI in this study
  6. fNo. of involved levels, when RPN was excluded and rare-neck areas were counted as one level
  7. *p < 0.05